Ovgp1 oviductal glycoprotein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ovgp1provided by MGI
Official Full Name: oviductal glycoprotein 1provided by MGI
Primary source: MGI:MGI:106661
See related: Ensembl:ENSMUSG00000074340 AllianceGenome:MGI:106661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OGP; MOGP; muc9; Chit5; 120kDa
Summary: Predicted to enable chitin binding activity and chitinase activity. Acts upstream of or within negative regulation of binding activity of sperm to zona pellucida. Located in egg coat and perivitelline space. Is expressed in oviduct and testis. Orthologous to human OVGP1 (oviductal glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 257.8) and testis adult (RPKM 8.3) See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 46.46 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (105881118..105894739)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (105973802..105987423)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9.
Title: Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9.
In the ovary, Ovgp1 transcripts and protein were detected in the surface epithelium, granulosa cells of the preantral and the antral follicles and corpus luteum. In both, the ovary and oviduct, the expression of Ovgp1 was found to be higher at estrus stage than at diestrus stage. To the best of our knowledge, this is the first study demonstrating the extra-oviductal expression of Ovgp1
Title: Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary.
Results suggest that the mRNA level of mouse cervix oviductin was related to estrous cycle,implied with estrogen-dependence.
Title: [Preliminary study on expression of oviductin in mouse cervix].
A line of OGP gene-null (ogp-/-) mice has been established and their reproductive properties have been primarily characterized; results indicate that OGP is not essential for the process of in vivo fertilization, at least in mice.
Title: Effect of a null mutation of the oviduct-specific glycoprotein gene on mouse fertilization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

RH136395 (e-PCR)
- UniSTS:210385

NoName (e-PCR)
- UniSTS:224985

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in egg coat	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in perivitelline space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: oviduct-specific glycoprotein

Names: chitinase 5; estrogen-dependent oviduct protein; mucin 9; oviduct glycoprotein OGP; oviductal glycoprotein 1, 120kD; oviductin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007696.2 → NP_031722.1 oviduct-specific glycoprotein precursor

See identical proteins and their annotated locations for NP_031722.1

Status: PROVISIONAL

Source sequence(s)

D32137

Consensus CDS

CCDS17716.1

UniProtKB/Swiss-Prot

Q62010

UniProtKB/TrEMBL

B9EHI6, Q54AJ4, Q5GJ02

Related

ENSMUSP00000000573.3, ENSMUST00000000573.9

Conserved Domains (2) summary

cd02872
Location:24 → 382

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

smart00636
Location:23 → 360

Glyco_18; Glyco_18 domain