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LOC126805591 BRD4-independent group 4 enhancer GRCh37_chr1:5045612-5046811 [ Homo sapiens (human) ]

Gene ID: 126805591, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126805591
Gene description
BRD4-independent group 4 enhancer GRCh37_chr1:5045612-5046811
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126805591 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (4985552..4986751)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (4501310..4502509)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4750784-4751735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4753674-4754174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4754175-4754675 Neighboring gene adherens junctions associated protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:4761588-4762504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:4762505-4763419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4763460-4763971 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:4766013-4766207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4769069-4769981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4770432-4771050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4771051-4771667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4793939-4794439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4804152-4804652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4804653-4805153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4811516-4812353 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:4814461-4815322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4822523-4823023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:4842233-4842751 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:4881125-4881715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:4929251-4929752 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:4957340-4957510 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:5025208-5026407 Neighboring gene long intergenic non-protein coding RNA 2781 Neighboring gene uncharacterized LOC124904589 Neighboring gene uncharacterized LOC102724429 Neighboring gene MPRA-validated peak22 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:5112177-5112908 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:5143570-5144769 Neighboring gene long intergenic non-protein coding RNA 2782

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081915.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    4985552..4986751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    4501310..4502509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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