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LOC126806880 MED14-independent group 3 enhancer GRCh37_chr3:177174687-177175886 [ Homo sapiens (human) ]

Gene ID: 126806880, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126806880
Gene description
MED14-independent group 3 enhancer GRCh37_chr3:177174687-177175886
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126806880 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (177456899..177458098)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (180260093..180261292)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986053 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:177001817-177002549 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:177006212-177006426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:177011460-177012659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20838 Neighboring gene MPRA-validated peak4933 silencer Neighboring gene long intergenic non-protein coding RNA 501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20839 Neighboring gene Sharpr-MPRA regulatory region 4767 Neighboring gene Sharpr-MPRA regulatory region 10654 Neighboring gene argininosuccinate synthetase 1 pseudogene 7 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:177062319-177062838 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:177063359-177063876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20842 Neighboring gene Sharpr-MPRA regulatory region 9868 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:177077317-177078158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:177083633-177084134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20847 Neighboring gene MPRA-validated peak4934 silencer Neighboring gene long intergenic non-protein coding RNA 578 Neighboring gene NANOG hESC enhancer GRCh37_chr3:177205476-177205977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:177234333-177235097 Neighboring gene RN7SK pseudogene 52 Neighboring gene uncharacterized LOC124906306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083201.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    177456899..177458098
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    180260093..180261292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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