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LOC126859959 BRD4-independent group 4 enhancer GRCh37_chr7:20866537-20867736 [ Homo sapiens (human) ]

Gene ID: 126859959, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126859959
Gene description
BRD4-independent group 4 enhancer GRCh37_chr7:20866537-20867736
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126859959 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (20826918..20828117)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (20962969..20964168)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:20681108-20682307 Neighboring gene NANOG hESC enhancer GRCh37_chr7:20693236-20693793 Neighboring gene ATP binding cassette subfamily B member 5 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:20815756-20816338 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:20816339-20816919 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:20822883-20823543 Neighboring gene VISTA enhancer hs844 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:20835446-20836154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17994 Neighboring gene VISTA enhancer hs1019 Neighboring gene NANOG hESC enhancer GRCh37_chr7:20855921-20856533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:20874484-20874984 Neighboring gene Sp8 transcription factor Neighboring gene long intergenic non-protein coding RNA 1162 Neighboring gene ribosomal protein L23 pseudogene 8 Neighboring gene ribosomal protein S26 pseudogene 30 Neighboring gene VISTA enhancer hs1007 Neighboring gene VISTA enhancer hs110 Neighboring gene VISTA enhancer hs1148 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:21050446-21051645 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:21069658-21070388 Neighboring gene VISTA enhancer hs1226 Neighboring gene VISTA enhancer hs701 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98226 Neighboring gene RNA, 7SL, cytoplasmic 542, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_084460.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    20826918..20828117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    20962969..20964168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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