U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126860686 CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:97780096-97781295 [ Homo sapiens (human) ]

Gene ID: 126860686, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126860686
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:97780096-97781295
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (95017814..95019013)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (107187172..107188371)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aminopeptidase O (putative) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:97587461-97588134 Neighboring gene microRNA 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28636 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97634019-97634518 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110405 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110431 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97678815-97679315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97680413-97680914 Neighboring gene uncharacterized LOC101928119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97689588-97690377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97690378-97691166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97691883-97692383 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:97712716-97712894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20058 Neighboring gene Sharpr-MPRA regulatory region 10357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97741836-97742834 Neighboring gene Sharpr-MPRA regulatory region 2222 Neighboring gene Sharpr-MPRA regulatory region 14176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20061 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:97785561-97786760 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:97791169-97791319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97794537-97795036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97807172-97807937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97825060-97825769 Neighboring gene microRNA 6081 Neighboring gene microRNA 23b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085186.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    95017814..95019013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    107187172..107188371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases