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LOC126861244 BRD4-independent group 4 enhancer GRCh37_chr11:68549035-68550234 [ Homo sapiens (human) ]

Gene ID: 126861244, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861244
Gene description
BRD4-independent group 4 enhancer GRCh37_chr11:68549035-68550234
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68781567..68782766)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68787698..68788897)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68474187-68474945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68479758-68480258 Neighboring gene testis expressed metallothionein like protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68518115-68519100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3678 Neighboring gene uncharacterized LOC124902699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68531008-68531810 Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68565881-68566380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68609778-68610303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5144 Neighboring gene uncharacterized LOC124902700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3685 Neighboring gene long intergenic non-protein coding RNA 2701

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085743.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    68781567..68782766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    68787698..68788897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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