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LOC126861694 CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:132269252-132270451 [ Homo sapiens (human) ]

Gene ID: 126861694, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861694
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:132269252-132270451
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (131784707..131785906)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (131828826..131830026)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132156613-132157112 Neighboring gene uncharacterized LOC105370087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7369 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:132204952-132206151 Neighboring gene splicing factor SWAP Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132213273-132213837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:132216488-132217157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:132217158-132217826 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:132221080-132222279 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132257981-132258606 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132258607-132259231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132271907-132272407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132280316-132281138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132281963-132282784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132284875-132285724 Neighboring gene RNA, 5S ribosomal pseudogene 378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132295853-132296798 Neighboring gene RNA, U6 small nuclear 1017, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086192.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    131784707..131785906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    131828826..131830026
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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