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LOC126861732 CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:33760051-33761250 [ Homo sapiens (human) ]

Gene ID: 126861732, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861732
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:33760051-33761250
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (33185914..33187113)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (32403019..32404218)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene TOMM22 pseudogene 3 Neighboring gene translation initiation factor IF-2-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:33590165-33590740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:33590741-33591318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7567 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:33666443-33666999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7569 Neighboring gene klotho Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7570 Neighboring gene StAR related lipid transfer domain containing 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7573 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:33770183-33770373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:33834523-33835023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7578 Neighboring gene STARD13 antisense RNA Neighboring gene long intergenic non-protein coding RNA 2344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086230.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    33185914..33187113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    32403019..32404218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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