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LOC126861750 BRD4-independent group 4 enhancer GRCh37_chr13:42933453-42934652 [ Homo sapiens (human) ]

Gene ID: 126861750, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861750
Gene description
BRD4-independent group 4 enhancer GRCh37_chr13:42933453-42934652
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861750 in Genome Data Viewer
Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (42359317..42360516)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (41579040..41580239)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase eta Neighboring gene CRISPRi-validated cis-regulatory element chr13.544 Neighboring gene CRISPRi-validated cis-regulatory element chr13.545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5298 Neighboring gene NANOG hESC enhancer GRCh37_chr13:42858188-42858689 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:42872570-42873769 Neighboring gene fumarate hydratase pseudogene 1 Neighboring gene A-kinase anchoring protein 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7646 Neighboring gene fatty acid binding protein 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5300 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:42979722-42980921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7649 Neighboring gene long intergenic non-protein coding RNA 2341

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086248.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    42359317..42360516
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    41579040..41580239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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