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LOC126861757 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:44761946-44763145 [ Homo sapiens (human) ]

Gene ID: 126861757, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861757
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:44761946-44763145
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (44187810..44189009)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (43407581..43408780)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene non-coding RNA in the aldehyde dehydrogenase 1A pathway Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:44653586-44654467 Neighboring gene long intergenic non-protein coding RNA 390 Neighboring gene SMIM2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:44715242-44716201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5304 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:44717815-44718009 Neighboring gene SMIM2 intronic transcript 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:44733325-44734524 Neighboring gene small integral membrane protein 2 Neighboring gene microRNA 8079 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:44805723-44806922 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:44824216-44824392 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:44837776-44838975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7673 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:44880060-44881259 Neighboring gene uncharacterized LOC107984552 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:44886104-44887303

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086255.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    44187810..44189009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    43407581..43408780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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