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LOC126861844 MED14-independent group 3 enhancer GRCh37_chr13:109752798-109753997 [ Homo sapiens (human) ]

Gene ID: 126861844, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861844
Gene description
MED14-independent group 3 enhancer GRCh37_chr13:109752798-109753997
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861844 in Genome Data Viewer
Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (109100450..109101649)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (108327840..108329039)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32209 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32236 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32244 Neighboring gene Sharpr-MPRA regulatory region 13714 Neighboring gene host cell factor C2 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32288 Neighboring gene myosin XVI Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32298 Neighboring gene NANOG hESC enhancer GRCh37_chr13:109270467-109270968 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:109304354-109304547 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:109487341-109487872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32390 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:109643265-109644464 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:109663206-109663857 Neighboring gene MYO16 antisense RNA 2 Neighboring gene uncharacterized LOC124903208 Neighboring gene uncharacterized LOC105370356 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:109807999-109809198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:109811697-109812202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086342.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    109100450..109101649
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    108327840..108329039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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