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LOC126862006 CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:78793548-78794747 [ Homo sapiens (human) ]

Gene ID: 126862006, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862006
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:78793548-78794747
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862006 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (78327205..78328404)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (72536200..72537399)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA suppressor (anticodon CTA) 3-1 Neighboring gene ribosomal protein S26 pseudogene 48 Neighboring gene neurexin 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8817 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36905 Neighboring gene MPRA-validated peak2214 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5982 Neighboring gene Sharpr-MPRA regulatory region 7209 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36943 Neighboring gene uncharacterized LOC105370589 Neighboring gene MPRA-validated peak2216 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:79358917-79359500 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:79359501-79360083 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:79400229-79400386 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:79451802-79452322 Neighboring gene uncharacterized LOC124903353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086504.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    78327205..78328404
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    72536200..72537399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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