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LOC126862059 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408 [ Homo sapiens (human) ]

Gene ID: 126862059, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862059
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126862059 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101730872..101732071)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95966611..95967810)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102086475-102087282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102088484-102089040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102089041-102089597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102089661-102090174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102090175-102090686 Neighboring gene long intergenic non-protein coding RNA 2320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102132807-102133306 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102155672-102155835 Neighboring gene ribosomal protein L26 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102174026-102174796 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102184781-102184986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102188573-102189513 Neighboring gene long intergenic non-protein coding RNA 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6102 Neighboring gene uncharacterized LOC107984658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6103 Neighboring gene protein phosphatase 2 regulatory subunit B'gamma Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9045 Neighboring gene uncharacterized LOC124903388 Neighboring gene RNA, U6 small nuclear 790, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 9043
  • ATAC-STARR-seq lymphoblastoid active region 9044

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086557.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    101730872..101732071
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    95966611..95967810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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