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LOC126862281 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672 [ Homo sapiens (human) ]

Gene ID: 126862281, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862281
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (7867021..7868670)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (7898636..7900285)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA binding fox-1 homolog 1 Neighboring gene uncharacterized LOC124903640 Neighboring gene NANOG hESC enhancer GRCh37_chr16:7481632-7482288 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:7701751-7702302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:7703336-7703942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:7758954-7760153 Neighboring gene uncharacterized LOC124900381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7814521-7815243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7815244-7815965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7819497-7820696 Neighboring gene uncharacterized LOC105371069 Neighboring gene MPRA-validated peak2490 silencer Neighboring gene MPRA-validated peak2491 silencer Neighboring gene MPRA-validated peak2492 silencer Neighboring gene uncharacterized LOC124903641

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • OCT4-NANOG hESC enhancer GRCh37_chr16:7917023-7917645

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086779.2 

    Range
    101..1750
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    7867021..7868670
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    7898636..7900285
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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