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LOC126862806 BRD4-independent group 4 enhancer GRCh37_chr18:73337297-73338496 [ Homo sapiens (human) ]

Gene ID: 126862806, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862806
Gene description
BRD4-independent group 4 enhancer GRCh37_chr18:73337297-73338496
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (75625342..75626541)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (75854712..75855911)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372201 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:73201370-73202569 Neighboring gene uncharacterized LOC105372202 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:73222091-73222736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73294662-73295162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73295163-73295663 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:73350103-73350680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:73350681-73351256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73405637-73406228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73405045-73405636 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:73423789-73424988 Neighboring gene long intergenic non-protein coding RNA 1898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73513709-73514215 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:73558425-73559064 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:73559065-73559702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73616131-73616632 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:73649128-73649670 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:73650329-73650828 Neighboring gene uncharacterized LOC105372203

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087303.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    75625342..75626541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    75854712..75855911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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