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LOC126862813 BRD4-independent group 4 enhancer GRCh37_chr18:74748403-74749602 [ Homo sapiens (human) ]

Gene ID: 126862813, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862813
Gene description
BRD4-independent group 4 enhancer GRCh37_chr18:74748403-74749602
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862813 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (77036447..77037646)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (77266817..77267982)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 236 Neighboring gene exportin for tRNA pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74651502-74652002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74678461-74679129 Neighboring gene uncharacterized LOC105372217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74694849-74695698 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:74700218-74701417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74704741-74705313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74709764-74710264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74710265-74710765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74717425-74718324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74718325-74719223 Neighboring gene myelin basic protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74757338-74757860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74765055-74765555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74766661-74767562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74770546-74771179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13521 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:74776675-74777874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13524 Neighboring gene uncharacterized LOC124904328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802305-74802806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802807-74803306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74804211-74804718 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74808602-74809360 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74809361-74810118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74811635-74812393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74823367-74823868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74823869-74824370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74825481-74826028 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:74830525-74831025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74831608-74832216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74832217-74832825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74835311-74836244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:74870262-74870762 Neighboring gene NANOG hESC enhancer GRCh37_chr18:74872399-74872969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:74938546-74939745 Neighboring gene uncharacterized LOC124904329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74961440-74962111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74962783-74963454 Neighboring gene galanin receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087310.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    77036447..77037646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    77266817..77267982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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