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Coro1a coronin, actin binding protein 1A [ Mus musculus (house mouse) ]

Gene ID: 12721, updated on 5-Jan-2022

Summary

Official Symbol
Coro1aprovided by MGI
Official Full Name
coronin, actin binding protein 1Aprovided by MGI
Primary source
MGI:MGI:1345961
See related
Ensembl:ENSMUSG00000030707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p57; Lmb3; TACO; Clabp
Summary
This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Biased expression in thymus adult (RPKM 522.1), spleen adult (RPKM 445.6) and 7 other tissues See more
Orthologs
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Genomic context

See Coro1a in Genome Data Viewer
Location:
7 69.25 cM; 7 F3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126298946..126303988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126699774..126704816, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133843288..133848268, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Neighboring gene bolA-like 2 (E. coli) Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 1 Neighboring gene mitogen-activated protein kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
lupus in MRL and B6 F2 cross, QTL 3
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within early endosome to recycling endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in natural killer cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nerve growth factor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in phagolysosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of actin polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within uropod organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in stereocilium tip EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-1A
Names
clipin-A
coronin 1
coronin-like actin binding protein
coronin-like protein A
coronin-like protein p57
tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301374.1NP_001288303.1  coronin-1A isoform 1

    See identical proteins and their annotated locations for NP_001288303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124505, AF047388, AK165296, BC053398, BY198241
    Consensus CDS
    CCDS21840.1
    UniProtKB/Swiss-Prot
    O89053
    UniProtKB/TrEMBL
    Q3U1N0
    Related
    ENSMUSP00000101972.2, ENSMUST00000106364.8
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_009898.3NP_034028.1  coronin-1A isoform 1

    See identical proteins and their annotated locations for NP_034028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124505, AK165296, BC053398, BY236847
    Consensus CDS
    CCDS21840.1
    UniProtKB/Swiss-Prot
    O89053
    UniProtKB/TrEMBL
    Q3U1N0
    Related
    ENSMUSP00000032949.8, ENSMUST00000032949.14
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126298946..126303988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507284.5XP_006507347.1  coronin-1A isoform X1

    See identical proteins and their annotated locations for XP_006507347.1

    UniProtKB/Swiss-Prot
    O89053
    UniProtKB/TrEMBL
    Q3U1N0
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006507285.4XP_006507348.1  coronin-1A isoform X1

    See identical proteins and their annotated locations for XP_006507348.1

    UniProtKB/Swiss-Prot
    O89053
    UniProtKB/TrEMBL
    Q3U1N0
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9461
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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