Format

Send to:

Choose Destination

Clk4 CDC like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 12750, updated on 23-Jun-2021

Summary

Official Symbol
Clk4provided by MGI
Official Full Name
CDC like kinase 4provided by MGI
Primary source
MGI:MGI:1098551
See related
Ensembl:ENSMUSG00000020385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C85119; AI987988
Expression
Ubiquitous expression in CNS E14 (RPKM 17.6), CNS E11.5 (RPKM 16.5) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Clk4 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51153941..51172597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51263114..51281770)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51076673..51095266)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 20 Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene cDNA sequence BC049762 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene heterogeneous nuclear ribonucleoprotein A/B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein kinase CLK4
NP_001291673.1
NP_001349464.1
NP_001349465.1
NP_001349467.1
NP_001349468.1
NP_001349469.1
NP_001349470.1
NP_031740.1
XP_006532175.1
XP_006532177.1
XP_006532181.1
XP_011247010.1
XP_017169732.1
XP_030101370.1
XP_030101371.1
XP_036012164.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304744.1NP_001291673.1  dual specificity protein kinase CLK4 isoform 2

    See identical proteins and their annotated locations for NP_001291673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    UniProtKB/Swiss-Prot
    O35493
    Related
    ENSMUSP00000104741.2, ENSMUST00000109113.8
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001362535.1NP_001349464.1  dual specificity protein kinase CLK4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:149478
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  3. NM_001362536.1NP_001349465.1  dual specificity protein kinase CLK4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:110439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  4. NM_001362538.1NP_001349467.1  dual specificity protein kinase CLK4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Conserved Domains (1) summary
    cd14213
    Location:110439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  5. NM_001362539.1NP_001349468.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001362540.1NP_001349469.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001362541.1NP_001349470.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS78942.1
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  8. NM_007714.6NP_031740.1  dual specificity protein kinase CLK4 isoform 1

    See identical proteins and their annotated locations for NP_031740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL645907
    Consensus CDS
    CCDS24651.1
    UniProtKB/Swiss-Prot
    O35493
    UniProtKB/TrEMBL
    Q4FJV9
    Related
    ENSMUSP00000090820.7, ENSMUST00000093132.13
    Conserved Domains (1) summary
    cd14213
    Location:146475
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51153941..51172597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532118.3XP_006532181.1  dual specificity protein kinase CLK4 isoform X4

    See identical proteins and their annotated locations for XP_006532181.1

    UniProtKB/Swiss-Prot
    O35493
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006532112.5XP_006532175.1  dual specificity protein kinase CLK4 isoform X3

    See identical proteins and their annotated locations for XP_006532175.1

    Conserved Domains (1) summary
    cd14213
    Location:110439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  3. XM_030245511.2XP_030101371.1  dual specificity protein kinase CLK4 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006532114.5XP_006532177.1  dual specificity protein kinase CLK4 isoform X4

    See identical proteins and their annotated locations for XP_006532177.1

    UniProtKB/Swiss-Prot
    O35493
    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017314243.2XP_017169732.1  dual specificity protein kinase CLK4 isoform X1

    Conserved Domains (1) summary
    cd14213
    Location:175504
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  6. XM_036156271.1XP_036012164.1  dual specificity protein kinase CLK4 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1295
    PKc_like; Protein Kinases, catalytic domain
  7. XM_030245510.2XP_030101370.1  dual specificity protein kinase CLK4 isoform X3

    Conserved Domains (1) summary
    cd14213
    Location:110439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
  8. XM_011248708.4XP_011247010.1  dual specificity protein kinase CLK4 isoform X2

    Conserved Domains (1) summary
    cd14213
    Location:155484
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
Support Center