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Clu clusterin [ Mus musculus (house mouse) ]

Gene ID: 12759, updated on 8-Jul-2021

Summary

Official Symbol
Cluprovided by MGI
Official Full Name
clusterinprovided by MGI
Primary source
MGI:MGI:88423
See related
Ensembl:ENSMUSG00000022037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; C; Sg; Cli; SP-; Sgp; ApoJ; Sgp2; Sugp; SP-40; Sgp-2; D14Ucl; Sugp-2; AI893575; D14Ucla3
Summary
The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]
Expression
Biased expression in genital fat pad adult (RPKM 3056.5), ovary adult (RPKM 788.7) and 11 other tissues See more
Orthologs
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Genomic context

See Clu in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66205932..66218997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65968483..65981548)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66587320..66600382)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41182 Neighboring gene scavenger receptor class A, member 3 Neighboring gene predicted gene, 19222 Neighboring gene gulonolactone (L-) oxidase Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carrier activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system myelin maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in immune complex clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to thapsigargin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to tunicamycin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
clusterin
Names
Apolipoprotein J
clustrin
complement lysis inhibitor
sulfated glycoprotein 2
testosterone repressed prostate message
testosterone repressed prostate message-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013492.3NP_038520.2  clusterin preproprotein

    See identical proteins and their annotated locations for NP_038520.2

    Status: REVIEWED

    Source sequence(s)
    BC075668, BP769702, BY248781
    Consensus CDS
    CCDS36957.1
    UniProtKB/Swiss-Prot
    Q06890
    UniProtKB/TrEMBL
    Q549A5
    Related
    ENSMUSP00000022616.7, ENSMUST00000022616.14
    Conserved Domains (1) summary
    pfam01093
    Location:29444
    Clusterin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66205932..66218997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518504.5XP_006518567.1  clusterin isoform X2

    See identical proteins and their annotated locations for XP_006518567.1

    UniProtKB/Swiss-Prot
    Q06890
    UniProtKB/TrEMBL
    Q549A5
    Conserved Domains (1) summary
    pfam01093
    Location:29444
    Clusterin
  2. XM_006518503.5XP_006518566.1  clusterin isoform X1

    Conserved Domains (1) summary
    pfam01093
    Location:39454
    Clusterin
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