U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC1276697 gamma-aminobutyric acid receptor subunit beta [ Anopheles gambiae (African malaria mosquito) ]

Gene ID: 1276697, updated on 31-Jan-2024

Summary

Go to the top of the page Help
Gene symbol
LOC1276697
Gene description
gamma-aminobutyric acid receptor subunit beta
Gene type
protein coding
RefSeq status
MODEL
Organism
Anopheles gambiae
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
Also known as
Rdl
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) 2 NC_064601.1 (94255896..94341446)

Chromosome 2 - NC_064601.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor 1 Neighboring gene glutamate receptor 1 Neighboring gene uncharacterized LOC1276699 Neighboring gene mitoferrin Neighboring gene probable nucleoporin Nup54 Neighboring gene uncharacterized LOC5667353

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_064601.1 Chromosome 2 Reference idAnoGambNW_F1_1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis. Du W, et al. Insect Mol Biol, 2005 Apr. PMID 15796751
  2. Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin. Taylor-Wells J, et al. Insect Biochem Mol Biol, 2018 Feb. PMID 29223796
  3. The Anopheles gambiae genome: an update. Mongin E, et al. Trends Parasitol, 2004 Feb. PMID 14747013
  4. The genome sequence of the malaria mosquito Anopheles gambiae. Holt RA, et al. Science, 2002 Oct 4. PMID 12364791

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA A-to-I editing alters the gene products of Rdl in three mosquito disease vectors, recoding five amino acid residues in RDL of Aedes aegypti and six residues in RDLs of Anopheles gambiae and Culex pipiens, which is the highest extent of editing in RDL observed to date. Analysis of An. gambiae Rdl cDNA sequences identified 24 editing isoforms demonstrating a considerable increase in gene product diversity.
    Title: Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin.
  2. Mutations in the Rdl locus (coding for a gamma-aminobutyric acid (GABA) receptor subunit) confer dieldrin resistance to Anopheles gambiae.
    Title: Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
gamma-aminobutyric acid receptor subunit beta
Names
RDL bd

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference idAnoGambNW_F1_1 Primary Assembly

Genomic

  1. NC_064601.1 Reference idAnoGambNW_F1_1 Primary Assembly

    Range
    94255896..94341446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_316071.5 → XP_316071.4  gamma-aminobutyric acid receptor subunit beta isoform X3

    See identical proteins and their annotated locations for XP_316071.4

    UniProtKB/TrEMBL
    Q7PII2
    Conserved Domains (2) summary
    TIGR00860
    Location:56 → 537
    LIC; Cation transporter family protein
    cd19008
    Location:78 → 261
    LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

  2. XM_001688723.2 → XP_001688775.1  gamma-aminobutyric acid receptor subunit beta isoform X1

    See identical proteins and their annotated locations for XP_001688775.1

    UniProtKB/TrEMBL
    A7UU05
    Conserved Domains (2) summary
    TIGR00860
    Location:56 → 537
    LIC; Cation transporter family protein
    cd19008
    Location:78 → 261
    LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

  3. XM_316070.5 → XP_316070.4  gamma-aminobutyric acid receptor subunit beta isoform X4

    See identical proteins and their annotated locations for XP_316070.4

    UniProtKB/TrEMBL
    Q7PII3
    Conserved Domains (3) summary
    TIGR00860
    Location:56 → 537
    LIC; Cation transporter family protein
    pfam02931
    Location:55 → 258
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:269 → 534
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. XM_061647962.1 → XP_061503946.1  gamma-aminobutyric acid receptor subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A1I9VT68

  5. XM_061647966.1 → XP_061503950.1  gamma-aminobutyric acid receptor subunit beta isoform X5

  6. XM_061647967.1 → XP_061503951.1  gamma-aminobutyric acid receptor subunit beta isoform X6

  7. XM_061647965.1 → XP_061503949.1  gamma-aminobutyric acid receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A7UU05

  8. XM_061647964.1 → XP_061503948.1  gamma-aminobutyric acid receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A7UU05

  9. XM_061647963.1 → XP_061503947.1  gamma-aminobutyric acid receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    A7UU05
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials