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Ccr7 chemokine (C-C motif) receptor 7 [ Mus musculus (house mouse) ]

Gene ID: 12775, updated on 6-Sep-2021

Summary

Official Symbol
Ccr7provided by MGI
Official Full Name
chemokine (C-C motif) receptor 7provided by MGI
Primary source
MGI:MGI:103011
See related
Ensembl:ENSMUSG00000037944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EBI; EBI1; CCR-7; CD197; Cmkbr; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
Expression
Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 70.1) and 2 other tissues See more
Orthologs
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Genomic context

See Ccr7 in Genome Data Viewer
Location:
11; 11 D
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99035025..99045903, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99144199..99155077, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (99005513..99016391, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4 Neighboring gene predicted gene, 32249 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables C-C motif chemokine 19 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C motif chemokine 19 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables C-C motif chemokine 21 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables chemokine (C-C motif) ligand 19 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine (C-C motif) ligand 19 binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine (C-C motif) ligand 21 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine (C-C motif) ligand 21 binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of T cell polarity TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in lymph node development TAS
Traceable Author Statement
more info
PubMed 
involved_in lymphocyte chemotaxis across high endothelial venule TAS
Traceable Author Statement
more info
PubMed 
involved_in lymphocyte migration into lymph node TAS
Traceable Author Statement
more info
PubMed 
involved_in mature conventional dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of leukocyte apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IC
Inferred by Curator
more info
PubMed 
acts_upstream_of positive regulation of JUN kinase activity IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of T cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell costimulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell proliferation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 1 cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of cell motility TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of thymocyte migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IC
Inferred by Curator
more info
PubMed 
involved_in regulation of dendritic cell dendrite assembly IC
Inferred by Curator
more info
PubMed 
involved_in regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tolerance induction to self antigen TAS
Traceable Author Statement
more info
PubMed 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nitric oxide TAS
Traceable Author Statement
more info
PubMed 
involved_in response to prostaglandin E TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-C chemokine receptor type 7
Names
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
chemokine (C-C) receptor 7
epstein-Barr virus-induced G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301713.1NP_001288642.1  C-C chemokine receptor type 7 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK037965, BF020112, BY194318
    UniProtKB/Swiss-Prot
    P47774
    Conserved Domains (1) summary
    pfam00001
    Location:12263
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_007719.2NP_031745.2  C-C chemokine receptor type 7 isoform a precursor

    See identical proteins and their annotated locations for NP_031745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK037965, BF020112
    Consensus CDS
    CCDS25373.1
    UniProtKB/Swiss-Prot
    P47774
    Related
    ENSMUSP00000099423.4, ENSMUST00000103134.4
    Conserved Domains (1) summary
    pfam00001
    Location:75326
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99035025..99045903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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