Cnga1 cyclic nucleotide gated channel alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnga1provided by MGI
Official Full Name: cyclic nucleotide gated channel alpha 1provided by MGI
Primary source: MGI:MGI:88436
See related: Ensembl:ENSMUSG00000067220 AllianceGenome:MGI:88436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cncg
Summary: Predicted to enable cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in membrane depolarization and regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within ion transport and visual perception. Located in photoreceptor outer segment membrane. Is expressed in photoreceptor layer outer segment; retina; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (72761039..72800095, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (72603696..72642752, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGA1.
Title: Retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGA1.
Numb protein interacts with Cnga1 in rod photoreceptor cilia to promote delivery of Cnga1.
Title: Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.
Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.
Title: Insulin receptor regulates photoreceptor CNG channel activity.
that effective knockdown of GUCY2E and CNGA1 expression to counteract loss of PDE6 function may develop into a valuable approach for treating some patients with RP.
Title: shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa.
Interaction with auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) is a major mechanism underlying proper expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Ih in vivo.
Title: Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.
Grb14 is a normal physiological modulator of CNG channel function in vivo.
Title: Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.
We demonstrate the association of photoreceptor CNG channels with membrane domains enriched in raft lipids and indicates, for the first time, that raft lipids modulate the plasma membrane localization and functional activity of photoreceptor CNG channels.
Title: Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M84742 (e-PCR)
- UniSTS:124993

M84742 (e-PCR)
- UniSTS:179171

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cGMP-gated cation channel alpha-1

Names: CNG channel alpha-1; CNG-1; CNG1; cyclic nucleotide gated channel, cGMP gated; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007723.2 → NP_031749.2 cGMP-gated cation channel alpha-1

See identical proteins and their annotated locations for NP_031749.2

Status: VALIDATED

Source sequence(s)

AC122733, BI738168, BI871897, CO423854, CX564336

Consensus CDS

CCDS19333.1

UniProtKB/Swiss-Prot

B9EJ09, P29974, Q60776

Related

ENSMUSP00000084464.6, ENSMUST00000087213.12

Conserved Domains (4) summary

COG0664
Location:465 → 621

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:471 → 587

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:179 → 399

Ion_trans; Ion transport protein

pfam16526
Location:587 → 657

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

72761039..72800095 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503709.1 → XP_006503772.1 cGMP-gated cation channel alpha-1 isoform X1

Conserved Domains (3) summary

cd00038
Location:486 → 602

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:172 → 414

Ion_trans; Ion transport protein

pfam16526
Location:602 → 671

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels