Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnpprovided by MGI
Official Full Name: 2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by MGI
Primary source: MGI:MGI:88437
See related: Ensembl:ENSMUSG00000006782 AllianceGenome:MGI:88437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnp1; Cnp-1; CNPase
Summary: Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within adult locomotory behavior; neurogenesis; and response to toxic substance. Located in cytoplasm; membrane; and myelin sheath. Is expressed in adrenal gland; central nervous system; gut; peripheral nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 129.1), cortex adult (RPKM 94.5) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100465765..100472565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100574909..100591875)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur.
Title: Normal pressure hydrocephalus decreases the proliferation of oligodendrocyte progenitor cells and the expression of CNPase and MOG proteins in the corpus callosum before behavioral deficits occur.
Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis.
Title: Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis.
Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments.
Title: Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments.
2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway
Title: 2',3'-Cyclic-nucleotide 3'-phosphodiesterase contributes to epithelial-mesenchymal transition of lens epithelial cells through the notch signalling pathway.
We hypothesize that PDE1 inhibition improves working memory performance by increasing prefrontal synaptic transmission and/or postsynaptic D1 receptor signaling, by modulating prefrontal downstream second messenger levels. These data, therefore, support the use of PDE1 inhibitors as a potential approach for the treatment of cognitive dysfunction.
Title: Targeting the dopamine D(1) receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.
CNP and RtcA fine-tune XBP1 output during ER stress
Title: The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress.
The results of this study suggested that with an appropriate reporter system Cnp activity can be used to define a proliferative subpopulation of NG2 cells committed to generate oligodendrocytes.
Title: Transient Cnp expression by early progenitors causes Cre-Lox-based reporter lines to map profoundly different fates.
CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).
Title: Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Data show atomic-resolution details of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) catalytic domain active site.
Title: Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
These data provide detailed novel insight into the complex effects of natriuretic peptides and their receptors on electrical conduction in the heart.
Title: Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cyclic nucleotide binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclic nucleotide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	ISO Inferred from Sequence Orthology more info
located_in myelin sheath adaxonal region	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Names: cyclic nucleotide phosphodiesterase 1

NP_001139790.1

EC 3.1.4.37

NP_034053.2

EC 3.1.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146318.1 → NP_001139790.1 2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 1

See identical proteins and their annotated locations for NP_001139790.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1). This isoform is also known as CNP1.

Source sequence(s)

AK087415, BY596086, M31810

UniProtKB/TrEMBL

Q3TYL9

Related

ENSMUST00000150414.8

Conserved Domains (2) summary

pfam05881
Location:166 → 399

CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)

pfam13671
Location:32 → 145

AAA_33; AAA domain
NM_009923.2 → NP_034053.2 2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2

See identical proteins and their annotated locations for NP_034053.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at an upstream start codon, compared to variant 1. The encoded protein (isoform 2) is 20 aa longer at the N-terminus, compared to isoform 1. This isoform is also known as CNP2.

Source sequence(s)

AK087415, AK158318, BY333311, BY596086

Consensus CDS

CCDS25427.1

UniProtKB/Swiss-Prot

P16330, Q61424, Q8C7C9, Q91V42, Q923F3

UniProtKB/TrEMBL

Q3TYV5

Related

ENSMUSP00000099409.5, ENSMUST00000103120.5

Conserved Domains (2) summary

pfam05881
Location:186 → 398

CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)

cl17190
Location:51 → 165

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...