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Cnr2 cannabinoid receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12802, updated on 11-Apr-2024

Summary

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Official Symbol
Cnr2provided by MGI
Official Full Name
cannabinoid receptor 2provided by MGI
Primary source
MGI:MGI:104650
See related
Ensembl:ENSMUSG00000062585 AllianceGenome:MGI:104650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CB2; CB-2; CB2-R
Summary
Predicted to enable cannabinoid receptor activity. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in dendrite; endoplasmic reticulum; and neuronal cell body. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 19.7), mammary gland adult (RPKM 6.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Cnr2 in Genome Data Viewer
Location:
4 D3; 4 68.01 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135622500..135647530)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135895189..135920219)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene STARR-positive B cell enhancer ABC_E1660 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene STARR-seq mESC enhancer starr_11738 Neighboring gene STARR-positive B cell enhancer ABC_E8000 Neighboring gene STARR-positive B cell enhancer ABC_E4684 Neighboring gene STARR-seq mESC enhancer starr_11739 Neighboring gene STARR-positive B cell enhancer ABC_E4685 Neighboring gene fucosidase, alpha-L- 1, tissue Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer. Iden JA, et al. Int J Mol Sci, 2023 Apr 24. PMID 37175480, Free PMC Article
  2. Cannabinoid CB2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. Kibret BG, et al. Behav Brain Res, 2023 Jun 25. PMID 37061199
  3. Structural basis of selective cannabinoid CB(2) receptor activation. Li X, et al. Nat Commun, 2023 Mar 15. PMID 36922494, Free PMC Article
  4. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. García-Blanco A, et al. Neurobiol Dis, 2023 Apr. PMID 36775043
  5. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice. Li J, et al. Brain Behav Immun, 2023 May. PMID 36754245

See all (332) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
    Title: Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
  2. The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
    Title: The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
  3. Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
    Title: Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells.
  4. Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
    Title: Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
  5. Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.
    Title: Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.
  6. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer.
    Title: The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer.
  7. CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
    Title: CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
  8. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans.
    Title: The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans.
  9. Role of CB2 cannabinoid receptor in the development of food addiction in male mice.
    Title: Role of CB2 cannabinoid receptor in the development of food addiction in male mice.
  10. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
    Title: Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy.
Submit: New GeneRIF Correction See all GeneRIFs (237)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cannabinoid receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cannabinoid receptor 2
Names
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305278.1 → NP_001292207.1  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_001292207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK036658, AK134109, FJ357035
    Consensus CDS
    CCDS18793.1
    UniProtKB/Swiss-Prot
    P47936, Q544H5
    Related
    ENSMUSP00000069957.4, ENSMUST00000068830.4
    Conserved Domains (2) summary
    pfam00001
    Location:50 → 299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42 → 314
    7tm_4; Olfactory receptor

  2. NM_009924.4 → NP_034054.3  cannabinoid receptor 2

    See identical proteins and their annotated locations for NP_034054.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK036658, AK037898, AK134109, AL672076, FJ357034, X86405
    Consensus CDS
    CCDS18793.1
    UniProtKB/Swiss-Prot
    P47936, Q544H5
    Related
    ENSMUSP00000095454.3, ENSMUST00000097843.9
    Conserved Domains (2) summary
    pfam00001
    Location:50 → 299
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42 → 314
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135622500..135647530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47936.1 GenPept UniProtKB/Swiss-Prot:P47936

Gene LinkOut

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