Cntf ciliary neurotrophic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cntfprovided by MGI
Official Full Name: ciliary neurotrophic factorprovided by MGI
Primary source: MGI:MGI:88439
See related: Ensembl:ENSMUSG00000079415 AllianceGenome:MGI:88439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. A read-through transcript variant composed of Zfp91 and Cntf sequences has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. [provided by RefSeq, Aug 2008]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 1.8), testis adult (RPKM 1.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.73 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (12740892..12742996, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (12763528..12765632, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel CNTF-mediated mechanism in stress-induced depressive-like behavior which points to opportunities for sex-specific treatments for depression, e.g. progesterone in females and CNTF-stimulating drugs in males.
Title: Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice.
This study demonstrated that the Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF.
Title: Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF.
Rod a-wave and cone b-wave amplitudes of electroretinograms were increased in Cntf (-/-) mice, but rod b-wave amplitudes were unchanged compared with those in WT mice. Up-regulated RPE65 and LRAT levels accelerated both the visual cycle rate and recovery rate of rod light sensitivity in Cntf (-/-) mice.
Title: Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments.
CNTF activates Akt-Nrf2 signaling to protect myocardial cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation.
Title: Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling.
HGF supports hindlimb motor neurons through c-Met; CNTF supports subsets of axial motor neurons through CNTFRalpha; and Artemin acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3/Syndecan-3 activation.
Title: Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Study provides new insights into the role of CNTF on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of up-regulation of matrix metalloproteinases through the Akt signaling pathway.
Title: Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt.
data suggest that All-trans retinoic acid administration upregulates CNTF expression in retinal pigment epithelial cells.
Title: All-trans retinoic acid upregulates the expression of ciliary neurotrophic factor in retinal pigment epithelial cells.
Our data reveal that haematopoietic cell-derived CNTF has roles in regulating BM B cell lymphopoiesis and both trabecular and cortical bone, the latter in a sex-dependent manner.
Title: Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.
CNTF is upregulated in the corticospinal tract after unilateral pyramidotomy, which likely triggers sprouting of uninjured axons.
Title: Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.
Results suggest that slowly up-regulated CNTF in the subventricular zone mediates stroke-induced neurogenesis and is counteracted by inflammation
Title: Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cntf (e-PCR), detects polymorphism
- UniSTS:507986

Cntf (e-PCR), detects polymorphism
- UniSTS:506808

AW545902 (e-PCR)
- UniSTS:181210

AI429687 (e-PCR)
- UniSTS:166127

Readthrough Gm44505

Readthrough gene: Gm44505, Included gene: Zfp91

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of photoreceptor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of retinal cell programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of retinal rod cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ciliary neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170786.2 → NP_740756.1 ciliary neurotrophic factor

See identical proteins and their annotated locations for NP_740756.1

Status: REVIEWED

Source sequence(s)

BC027539, BQ033243, W08735

Consensus CDS

CCDS29637.1

UniProtKB/Swiss-Prot

P51642

UniProtKB/TrEMBL

Q544D1

Related

ENSMUSP00000108555.2, ENSMUST00000112933.2

Conserved Domains (1) summary

pfam01110
Location:1 → 182

CNTF; Ciliary neurotrophic factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

12740892..12742996 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053007.2: Suppressed sequence

Description

NM_053007.2: This RefSeq was permanently suppressed because it actually represents the Zfp91-Cntf readthrough transcript, and not just Cntf.