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MRPL55 mitochondrial ribosomal protein L55 [ Homo sapiens (human) ]

Gene ID: 128308, updated on 5-Mar-2024

Summary

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Official Symbol
MRPL55provided by HGNC
Official Full Name
mitochondrial ribosomal protein L55provided by HGNC
Primary source
HGNC:HGNC:16686
See related
Ensembl:ENSG00000162910 MIM:611859; AllianceGenome:HGNC:16686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L55nt; bL31m; MRP-L55; AAVG5835; PRO19675
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.8), prostate (RPKM 8.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See MRPL55 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228106685..228109299, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227295671..227315175, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228294386..228297000, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:228284937-228286136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2689 Neighboring gene microRNA 3620 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289072-228289792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289793-228290512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228290513-228291233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228291234-228291953 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228295219-228295933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228295934-228296647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1913 Neighboring gene CIAO2A pseudogene 2 Neighboring gene ribosomal protein S28 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. O'Brien TW. Gene, 2002 Mar 6. PMID 11943462
  2. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
  4. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  5. Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics. Hou C, et al. Proteome Sci, 2018. PMID 29491746, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC61802, DKFZp686D1387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL55
Names
39S ribosomal protein L55, mitochondrial
L55mt
mitochondrial large ribosomal subunit protein bL31m
mitochondrial large ribosomal subunit protein mL55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321284.2 → NP_001308213.1  large ribosomal subunit protein mL55 isoform a

    Status: REVIEWED

    Source sequence(s)
    BC052806, BQ011059, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355708.3, ENST00000366747.7
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  2. NM_181441.3 → NP_852106.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BM975134, BP871687, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000338189.5, ENST00000348259.9
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  3. NM_181454.3 → NP_852119.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355700.1, ENST00000366739.5
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  4. NM_181455.3 → NP_852120.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BF945771, BM706934, BQ012917, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000375740.3, ENST00000391867.8
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  5. NM_181456.3 → NP_852121.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU597178
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000337361.5, ENST00000336300.9
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  6. NM_181462.3 → NP_852127.2  large ribosomal subunit protein mL55 isoform b

    See identical proteins and their annotated locations for NP_852127.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame segment when compared to variant 5. The predicted protein (isoform b) is longer than isoform a. The predicted ORF of this transcript has not been experimentally confirmed.
    Source sequence(s)
    AY358771, BI458525, BQ012917
    Consensus CDS
    CCDS44325.1
    UniProtKB/Swiss-Prot
    Q7Z7F7
    Related
    ENSP00000403614.1, ENST00000430433.5
    Conserved Domains (1) summary
    pfam09776
    Location:47 → 161
    Mitoc_L55; Mitochondrial ribosomal protein L55

  7. NM_181463.3 → NP_852128.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is the most commonly occurring transcript. Variants 1, 2, 3, 5, 6, 7, 8 encode the same isoform (a).
    Source sequence(s)
    BI458525, BQ012917, BU601595
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000337342.3, ENST00000336520.8
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  8. NM_181464.3 → NP_852129.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a different splice site in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU594505, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000295008.4, ENST00000295008.8
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  9. NM_181465.3 → NP_852130.1  large ribosomal subunit protein mL55 isoform a

    See identical proteins and their annotated locations for NP_852130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses a different splice site in one segment and lacks an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
    Source sequence(s)
    BQ012917, BU597178, CV572808
    Consensus CDS
    CCDS1567.1
    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355707.3, ENST00000366746.7
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228106685..228109299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446137.1 → XP_047302093.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  2. XM_047446143.1 → XP_047302099.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  3. XM_047446133.1 → XP_047302089.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  4. XM_005273062.4 → XP_005273119.1  large ribosomal subunit protein mL55 isoform X1

    See identical proteins and their annotated locations for XP_005273119.1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355703.1, ENST00000366742.5
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  5. XM_047446139.1 → XP_047302095.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  6. XM_047446096.1 → XP_047302052.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355695.1, ENST00000366734.5

  7. XM_047446113.1 → XP_047302069.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  8. XM_047446123.1 → XP_047302079.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355705.1, ENST00000366744.5

  9. XM_047446106.1 → XP_047302062.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  10. XM_005273061.6 → XP_005273118.1  large ribosomal subunit protein mL55 isoform X1

    See identical proteins and their annotated locations for XP_005273118.1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  11. XM_047446095.1 → XP_047302051.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  12. XM_047446098.1 → XP_047302054.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  13. XM_005273063.6 → XP_005273120.1  large ribosomal subunit protein mL55 isoform X1

    See identical proteins and their annotated locations for XP_005273120.1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  14. XM_011544095.4 → XP_011542397.1  large ribosomal subunit protein mL55 isoform X1

    See identical proteins and their annotated locations for XP_011542397.1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

  15. XM_047446079.1 → XP_047302035.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  16. XM_005273059.4 → XP_005273116.1  large ribosomal subunit protein mL55 isoform X1

    See identical proteins and their annotated locations for XP_005273116.1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Related
    ENSP00000355694.1, ENST00000366733.5
    Conserved Domains (1) summary
    pfam09776
    Location:11 → 125
    Mitoc_L55; Mitochondrial ribosomal protein L55

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227295671..227315175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334443.1 → XP_054190418.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  2. XM_054334446.1 → XP_054190421.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  3. XM_054334448.1 → XP_054190423.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  4. XM_054334445.1 → XP_054190420.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  5. XM_054334440.1 → XP_054190415.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  6. XM_054334447.1 → XP_054190422.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  7. XM_054334438.1 → XP_054190413.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  8. XM_054334442.1 → XP_054190417.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  9. XM_054334444.1 → XP_054190419.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  10. XM_054334441.1 → XP_054190416.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  11. XM_054334434.1 → XP_054190409.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  12. XM_054334437.1 → XP_054190412.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  13. XM_054334439.1 → XP_054190414.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  14. XM_054334433.1 → XP_054190408.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  15. XM_054334436.1 → XP_054190411.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  16. XM_054334432.1 → XP_054190407.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  17. XM_054334435.1 → XP_054190410.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

  18. XM_054334431.1 → XP_054190406.1  large ribosomal subunit protein mL55 isoform X1

    UniProtKB/Swiss-Prot
    Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7F7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7F7

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