Cox17 cytochrome c oxidase assembly protein 17, copper chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox17provided by MGI
Official Full Name: cytochrome c oxidase assembly protein 17, copper chaperoneprovided by MGI
Primary source: MGI:MGI:1333806
See related: Ensembl:ENSMUSG00000046516 AllianceGenome:MGI:1333806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables copper ion binding activity and enzyme activator activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly; positive regulation of cell population proliferation; and positive regulation of cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in brain; heart; metanephros; and skeletal muscle. Orthologous to human COX17 (cytochrome c oxidase copper chaperone COX17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 48.4), placenta adult (RPKM 37.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 26.77 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38167332..38173125)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38346983..38352763)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Title: COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
cox17 has a role in activating cytochrome c oxidase in mice
Title: Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.
Sp1, NRF-1 and NRF-2 are involved in basal transcription, similar to the transcription mechanism of other CCO-related genes
Title: Characterization and identification of promoter elements in the mouse COX17 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase copper chaperone

Names: cytochrome c oxidase, subunit XVII assembly protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.