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Cpe carboxypeptidase E [ Mus musculus (house mouse) ]

Gene ID: 12876, updated on 6-May-2021

Summary

Official Symbol
Cpeprovided by MGI
Official Full Name
carboxypeptidase Eprovided by MGI
Primary source
MGI:MGI:101932
See related
Ensembl:ENSMUSG00000037852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CP; CPH; fat; Cph-; Cph1; NF-a; Cph-1; R74677; NF-alpha1
Summary
This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]
Expression
Biased expression in frontal lobe adult (RPKM 416.8), cortex adult (RPKM 400.4) and 14 other tissues See more
Orthologs
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Genomic context

See Cpe in Genome Data Viewer
Location:
8 B3.1; 8 32.3 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65045576..65146143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64592542..64693109, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (67071339..67171837, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35521 Neighboring gene microRNA 710 Neighboring gene methylsterol monoxygenase 1 Neighboring gene kelch-like 2, Mayven Neighboring gene predicted gene, 46040

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7101

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cobalt ion binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within enkephalin processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peptide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to secretory granule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carboxypeptidase E
Names
carboxypeptidase H
enkephalin convertase
prohormone-processing carboxypeptidase
NP_038522.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013494.4NP_038522.2  carboxypeptidase E preproprotein

    See identical proteins and their annotated locations for NP_038522.2

    Status: REVIEWED

    Source sequence(s)
    AK047891, BE849320, CX241703
    Consensus CDS
    CCDS22327.1
    UniProtKB/Swiss-Prot
    Q00493
    UniProtKB/TrEMBL
    Q543R4
    Related
    ENSMUSP00000048555.8, ENSMUST00000048967.9
    Conserved Domains (2) summary
    cd11308
    Location:375449
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:49371
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65045576..65146143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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