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Cplx1 complexin 1 [ Mus musculus (house mouse) ]

Gene ID: 12889, updated on 8-Jul-2021

Summary

Official Symbol
Cplx1provided by MGI
Official Full Name
complexin 1provided by MGI
Primary source
MGI:MGI:104727
See related
Ensembl:ENSMUSG00000033615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
921-; 921-S
Expression
Biased expression in cerebellum adult (RPKM 127.9), frontal lobe adult (RPKM 105.0) and 3 other tissues See more
Orthologs
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Genomic context

See Cplx1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108666420..108697893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108518554..108550027, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108947573..108979046, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 3 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-1
Names
CPX I
complexin I
synaphin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007756.3NP_031782.3  complexin-1

    See identical proteins and their annotated locations for NP_031782.3

    Status: VALIDATED

    Source sequence(s)
    AK159026, BY278933, BY594213
    Consensus CDS
    CCDS39206.1
    UniProtKB/Swiss-Prot
    P63040
    Related
    ENSMUSP00000038502.10, ENSMUST00000046892.10
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108666420..108697893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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