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TANGO2 transport and golgi organization 2 homolog [ Homo sapiens (human) ]

Gene ID: 128989, updated on 3-Apr-2024

Summary

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Official Symbol
TANGO2provided by HGNC
Official Full Name
transport and golgi organization 2 homologprovided by HGNC
Primary source
HGNC:HGNC:25439
See related
Ensembl:ENSG00000183597 MIM:616830; AllianceGenome:HGNC:25439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MECRCN; C22orf25
Summary
This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
22q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20017023..20067164)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20394641..20444782)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20004546..20054687)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19951049-19951764 Neighboring gene microRNA 4761 Neighboring gene ARVCF delta catenin family member Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19970318-19971255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19971256-19972192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19973130-19974065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13470 Neighboring gene uncharacterized LOC124905082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19998201-19999025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20018676-20019372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18669 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20026069-20026230 Neighboring gene microRNA 185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20045081-20045581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20053631-20054131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18670 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:20070687-20071305 Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene microRNA 1306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mitochondrial dysfunction associated with TANGO2 deficiency. Heiman P, et al. Sci Rep, 2022 Feb 23. PMID 35197517, Free PMC Article
  2. Variable clinical severity in TANGO2 deficiency: Case series and literature review. Schymick J, et al. Am J Med Genet A, 2022 Feb. PMID 34668327
  3. Clinical phenotype associated with TANGO2 gene mutation. Hoebeke C, et al. Arch Pediatr, 2021 Jan. PMID 33342685
  4. Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect. Bérat CM, et al. J Inherit Metab Dis, 2021 Mar. PMID 32929747
  5. The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria. Milev MP, et al. J Inherit Metab Dis, 2021 Mar. PMID 32909282

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
    Title: Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
  2. Variable clinical severity in TANGO2 deficiency: Case series and literature review.
    Title: Variable clinical severity in TANGO2 deficiency: Case series and literature review.
  3. Mitochondrial dysfunction associated with TANGO2 deficiency.
    Title: Mitochondrial dysfunction associated with TANGO2 deficiency.
  4. Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect.
    Title: Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect.
  5. The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.
    Title: The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.
  6. Clinical phenotype associated with TANGO2 gene mutation.
    Title: Clinical phenotype associated with TANGO2 gene mutation.
  7. Clinical presentation and proteomic signature of patients with TANGO2 mutations.
    Title: Clinical presentation and proteomic signature of patients with TANGO2 mutations.
  8. TANGO2 deficiency as a cause of neurodevelopmental delay with indirect effects on mitochondrial energy metabolism.
    Title: TANGO2 deficiency as a cause of neurodevelopmental delay with indirect effects on mitochondrial energy metabolism.
  9. Variants from the 14 patients described are shown above the gene depiction with red bars for deletions and lines for single nucleotide variants (SNV), and pathogenic variants from prior studies are shown below (light blue bars for deletions and lines for SNV) based on TANGO2 transcript NM152906.6 (2623 bp).
    Title: TANGO2: expanding the clinical phenotype and spectrum of pathogenic variants.
  10. Exons 3-9 heterozygous deletion in TANGO2 are recurrent pathogenic alleles present in the Latino/Hispanic and European populations, respectively, causing considerable morbidity in the homozygotes in these populations.
    Title: Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761P1121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transport and Golgi organization protein 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046857.1 RefSeqGene

    Range
    9111..55165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001283106.3 → NP_001270035.1  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_001270035.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK289862, BC041339, DC303300, HY135099
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  2. NM_001283116.3 → NP_001270045.1  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_001270045.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, CF552364, DA176876
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  3. NM_001283129.3 → NP_001270058.1  transport and Golgi organization protein 2 homolog isoform b

    See identical proteins and their annotated locations for NP_001270058.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK316056, BC041339
    Consensus CDS
    CCDS63405.1
    UniProtKB/TrEMBL
    A8K1E7
    Related
    ENSP00000403645.2, ENST00000456048.5
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 300
    TANGO2; Transport and Golgi organization 2

  4. NM_001283148.3 → NP_001270077.1  transport and Golgi organization protein 2 homolog isoform c

    See identical proteins and their annotated locations for NP_001270077.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK316020, BC041339, DA176876
    UniProtKB/TrEMBL
    B7Z4V5, B7Z9Q5
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 201
    TANGO2; Transport and Golgi organization 2

  5. NM_001283154.3 → NP_001270083.1  transport and Golgi organization protein 2 homolog isoform c

    See identical proteins and their annotated locations for NP_001270083.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BI544307, BU173566
    UniProtKB/TrEMBL
    B7Z4V5, B7Z9Q5
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 201
    TANGO2; Transport and Golgi organization 2

  6. NM_001283179.3 → NP_001270108.1  transport and Golgi organization protein 2 homolog isoform d

    See identical proteins and their annotated locations for NP_001270108.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BX345246, DC303300, HY135099
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000385662.1, ENST00000401886.5
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 197
    TANGO2; Transport and Golgi organisation 2

  7. NM_001283186.3 → NP_001270115.1  transport and Golgi organization protein 2 homolog isoform d

    See identical proteins and their annotated locations for NP_001270115.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK092484, BC041339, DA176876
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000381122.2, ENST00000398042.6
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 197
    TANGO2; Transport and Golgi organisation 2

  8. NM_001283199.3 → NP_001270128.1  transport and Golgi organization protein 2 homolog isoform e

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BI544307, BI911898
    Consensus CDS
    CCDS74821.1
    UniProtKB/TrEMBL
    A0A0A0MSI5
    Related
    ENSP00000389797.3, ENST00000447208.6
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 184
    TANGO2; Transport and Golgi organization 2

  9. NM_001283215.3 → NP_001270144.1  transport and Golgi organization protein 2 homolog isoform f

    See identical proteins and their annotated locations for NP_001270144.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK301366, AK316056, BC041339
    Consensus CDS
    CCDS63406.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000391262.2, ENST00000434570.6
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 192
    TANGO2; Transport and Golgi organization 2

  10. NM_001283235.3 → NP_001270164.1  transport and Golgi organization protein 2 homolog isoform g

    See identical proteins and their annotated locations for NP_001270164.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK298593, BC041339, DA176876
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000402926.2, ENST00000432883.5
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  11. NM_001283248.3 → NP_001270177.1  transport and Golgi organization protein 2 homolog isoform h

    See identical proteins and their annotated locations for NP_001270177.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK297075, BC041339, DA176876
    Consensus CDS
    CCDS74822.1
    UniProtKB/TrEMBL
    B7Z4A5, C9JKN2
    Related
    ENSP00000396182.3, ENST00000420290.6
    Conserved Domains (1) summary
    cl01315
    Location:1 → 89
    TANGO2; Transport and Golgi organization 2

  12. NM_001322141.2 → NP_001309070.1  transport and Golgi organization protein 2 homolog isoform i

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BG685068, BP193987
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 352
    TANGO2; Transport and Golgi organization 2

  13. NM_001322142.2 → NP_001309071.1  transport and Golgi organization protein 2 homolog isoform j

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 311
    TANGO2; Transport and Golgi organization 2

  14. NM_001322143.2 → NP_001309072.1  transport and Golgi organization protein 2 homolog isoform b

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, AL713640, BM013784, DB021425
    Consensus CDS
    CCDS63405.1
    UniProtKB/TrEMBL
    A8K1E7
    Related
    ENSP00000384827.1, ENST00000401833.5
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 300
    TANGO2; Transport and Golgi organization 2

  15. NM_001322144.2 → NP_001309073.1  transport and Golgi organization protein 2 homolog isoform l

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    UniProtKB/TrEMBL
    B7Z4V5
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 242
    TANGO2; Transport and Golgi organization 2

  16. NM_001322145.2 → NP_001309074.1  transport and Golgi organization protein 2 homolog isoform m

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 238
    TANGO2; Transport and Golgi organization 2

  17. NM_001322146.2 → NP_001309075.1  transport and Golgi organization protein 2 homolog isoform k

    Status: REVIEWED

    Source sequence(s)
    AA319727, AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:55 → 277
    TANGO2; Transport and Golgi organization 2

  18. NM_001322147.2 → NP_001309076.1  transport and Golgi organization protein 2 homolog isoform m

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 238
    TANGO2; Transport and Golgi organization 2

  19. NM_001322148.2 → NP_001309077.1  transport and Golgi organization protein 2 homolog isoform n

    Status: REVIEWED

    Source sequence(s)
    AC006547, AK316056, BM048105
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:55 → 225
    TANGO2; Transport and Golgi organisation 2

  20. NM_001322149.2 → NP_001309078.1  transport and Golgi organization protein 2 homolog isoform r

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BI911898, DC349456
    Conserved Domains (1) summary
    pfam05742
    Location:60 → 225
    TANGO2; Transport and Golgi organization 2

  21. NM_001322150.2 → NP_001309079.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BP193987
    Conserved Domains (1) summary
    cl01315
    Location:32 → 213
    TANGO2; Transport and Golgi organization 2

  22. NM_001322153.2 → NP_001309082.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC006547, DC301369, DC315148
    Conserved Domains (1) summary
    cl01315
    Location:32 → 213
    TANGO2; Transport and Golgi organization 2

  23. NM_001322155.2 → NP_001309084.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    cl01315
    Location:32 → 213
    TANGO2; Transport and Golgi organization 2

  24. NM_001322160.2 → NP_001309089.1  transport and Golgi organization protein 2 homolog isoform p

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    cl01315
    Location:55 → 167
    TANGO2; Transport and Golgi organization 2

  25. NM_001322163.2 → NP_001309092.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 197
    TANGO2; Transport and Golgi organisation 2

  26. NM_001322166.2 → NP_001309095.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 197
    TANGO2; Transport and Golgi organisation 2

  27. NM_001322167.2 → NP_001309096.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 197
    TANGO2; Transport and Golgi organisation 2

  28. NM_001322169.2 → NP_001309098.1  transport and Golgi organization protein 2 homolog isoform q

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 139
    TANGO2; Transport and Golgi organization 2

  29. NM_001322171.2 → NP_001309100.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BF726547, CD675132
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  30. NM_001322172.2 → NP_001309101.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BF726547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  31. NM_001322173.2 → NP_001309102.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  32. NM_001322174.2 → NP_001309103.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  33. NM_001322175.2 → NP_001309104.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:32 → 161
    TANGO2; Transport and Golgi organisation 2

  34. NM_152906.7 → NP_690870.3  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_690870.3

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK297922, BC041339
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
    UniProtKB/TrEMBL
    A8K1E7
    Related
    ENSP00000332721.4, ENST00000327374.9
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

RNA

  1. NR_104274.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK301054, BC041339

  2. NR_104275.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547

  3. NR_136206.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547

  4. NR_136211.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006547, BI544307, BP303570

  5. NR_136212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20017023..20067164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028580.2 → XP_016884069.1  transport and Golgi organization protein 2 homolog isoform X2

    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 311
    TANGO2; Transport and Golgi organization 2

  2. XM_047441121.1 → XP_047297077.1  transport and Golgi organization protein 2 homolog isoform X3

  3. XM_017028579.2 → XP_016884068.1  transport and Golgi organization protein 2 homolog isoform X2

    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 311
    TANGO2; Transport and Golgi organization 2

  4. XM_047441124.1 → XP_047297080.1  transport and Golgi organization protein 2 homolog isoform X6

    UniProtKB/Swiss-Prot
    A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16

  5. XM_047441118.1 → XP_047297074.1  transport and Golgi organization protein 2 homolog isoform X1

  6. XM_047441131.1 → XP_047297087.1  transport and Golgi organization protein 2 homolog isoform X12

  7. XM_047441119.1 → XP_047297075.1  transport and Golgi organization protein 2 homolog isoform X3

  8. XM_017028577.2 → XP_016884066.1  transport and Golgi organization protein 2 homolog isoform X2

    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 311
    TANGO2; Transport and Golgi organization 2

  9. XM_017028585.2 → XP_016884074.1  transport and Golgi organization protein 2 homolog isoform X7

  10. XM_047441123.1 → XP_047297079.1  transport and Golgi organization protein 2 homolog isoform X5

  11. XM_047441130.1 → XP_047297086.1  transport and Golgi organization protein 2 homolog isoform X11

  12. XM_047441125.1 → XP_047297081.1  transport and Golgi organization protein 2 homolog isoform X8

  13. XM_047441126.1 → XP_047297082.1  transport and Golgi organization protein 2 homolog isoform X8

  14. XM_047441128.1 → XP_047297084.1  transport and Golgi organization protein 2 homolog isoform X9

  15. XM_047441127.1 → XP_047297083.1  transport and Golgi organization protein 2 homolog isoform X8

  16. XM_047441129.1 → XP_047297085.1  transport and Golgi organization protein 2 homolog isoform X10

  17. XM_047441122.1 → XP_047297078.1  transport and Golgi organization protein 2 homolog isoform X4

  18. XM_047441120.1 → XP_047297076.1  transport and Golgi organization protein 2 homolog isoform X3

  19. XM_047441132.1 → XP_047297088.1  transport and Golgi organization protein 2 homolog isoform X13

    UniProtKB/TrEMBL
    A0A0A0MSI5

  20. XM_017028586.2 → XP_016884075.1  transport and Golgi organization protein 2 homolog isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20394641..20444782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325065.1 → XP_054181040.1  transport and Golgi organization protein 2 homolog isoform X2

  2. XM_054325069.1 → XP_054181044.1  transport and Golgi organization protein 2 homolog isoform X3

  3. XM_054325066.1 → XP_054181041.1  transport and Golgi organization protein 2 homolog isoform X2

  4. XM_054325072.1 → XP_054181047.1  transport and Golgi organization protein 2 homolog isoform X6

    UniProtKB/Swiss-Prot
    A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16

  5. XM_054325063.1 → XP_054181038.1  transport and Golgi organization protein 2 homolog isoform X1

  6. XM_054325081.1 → XP_054181056.1  transport and Golgi organization protein 2 homolog isoform X12

  7. XM_054325068.1 → XP_054181043.1  transport and Golgi organization protein 2 homolog isoform X3

  8. XM_054325064.1 → XP_054181039.1  transport and Golgi organization protein 2 homolog isoform X2

  9. XM_054325074.1 → XP_054181049.1  transport and Golgi organization protein 2 homolog isoform X7

  10. XM_054325067.1 → XP_054181042.1  transport and Golgi organization protein 2 homolog isoform X3

  11. XM_054325082.1 → XP_054181057.1  transport and Golgi organization protein 2 homolog isoform X13

    UniProtKB/TrEMBL
    A0A0A0MSI5

  12. XM_054325073.1 → XP_054181048.1  transport and Golgi organization protein 2 homolog isoform X7

  13. XM_054325070.1 → XP_054181045.1  transport and Golgi organization protein 2 homolog isoform X4

  14. XM_054325071.1 → XP_054181046.1  transport and Golgi organization protein 2 homolog isoform X5

  15. XM_054325080.1 → XP_054181055.1  transport and Golgi organization protein 2 homolog isoform X11

  16. XM_054325075.1 → XP_054181050.1  transport and Golgi organization protein 2 homolog isoform X8

  17. XM_054325076.1 → XP_054181051.1  transport and Golgi organization protein 2 homolog isoform X8

  18. XM_054325078.1 → XP_054181053.1  transport and Golgi organization protein 2 homolog isoform X9

  19. XM_054325077.1 → XP_054181052.1  transport and Golgi organization protein 2 homolog isoform X8

  20. XM_054325084.1 → XP_054181059.1  transport and Golgi organization protein 2 homolog isoform X14

    UniProtKB/TrEMBL
    A8MWT1

  21. XM_054325079.1 → XP_054181054.1  transport and Golgi organization protein 2 homolog isoform X10

  22. XM_054325083.1 → XP_054181058.1  transport and Golgi organization protein 2 homolog isoform X14

    UniProtKB/TrEMBL
    A8MWT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ICL3.1 GenPept UniProtKB/Swiss-Prot:Q6ICL3

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