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Dpysl2 dihydropyrimidinase-like 2 [ Mus musculus (house mouse) ]

Gene ID: 12934, updated on 22-Aug-2021

Summary

Official Symbol
Dpysl2provided by MGI
Official Full Name
dihydropyrimidinase-like 2provided by MGI
Primary source
MGI:MGI:1349763
See related
Ensembl:ENSMUSG00000022048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DR; Ul; Crm; DRP2; Crmp2; TOAD-; Ulip2; TOAD-64; AI851130; Musunc33
Expression
Broad expression in CNS E18 (RPKM 51.3), whole brain E14.5 (RPKM 47.9) and 23 other tissues See more
Orthologs
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Genomic context

See Dpysl2 in Genome Data Viewer
Location:
14 D1; 14 34.6 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67040313..67148490, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66802864..66911041, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (67421701..67487437, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568160 Neighboring gene predicted gene 9130 Neighboring gene predicted gene 5464 Neighboring gene paraneoplastic antigen MA2 Neighboring gene predicted gene, 24258 Neighboring gene cold shock domain containing E1, RNA binding pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 2
Names
DRP-2
ULIP-2
collapsin response mediator protein 2
unc-33-like phosphoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378767.1NP_001365696.1  dihydropyrimidinase-related protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154693, AC165148
    Conserved Domains (1) summary
    cd01314
    Location:118567
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. NM_009955.3NP_034085.2  dihydropyrimidinase-related protein 2 isoform 2

    See identical proteins and their annotated locations for NP_034085.2

    Status: VALIDATED

    Source sequence(s)
    AC154693, BC062955
    Consensus CDS
    CCDS27224.1
    UniProtKB/Swiss-Prot
    O08553
    Related
    ENSMUSP00000022629.9, ENSMUST00000022629.9
    Conserved Domains (1) summary
    cd01314
    Location:17466
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    67040313..67148490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158432.1XP_036014325.1  dihydropyrimidinase-related protein 2 isoform X1

    Conserved Domains (1) summary
    cd01314
    Location:5454
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
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