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Dmbt1 deleted in malignant brain tumors 1 [ Mus musculus (house mouse) ]

Gene ID: 12945, updated on 29-May-2021

Summary

Official Symbol
Dmbt1provided by MGI
Official Full Name
deleted in malignant brain tumors 1provided by MGI
Primary source
MGI:MGI:106210
See related
Ensembl:ENSMUSG00000047517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cr; he; CRP; MUC; ebn; p80; CRP-; Crpd; gp30; CRP-[; DBMT1; gp300; CRP-[a]; CRP-[b]
Expression
Biased expression in colon adult (RPKM 494.9), large intestine adult (RPKM 367.0) and 4 other tissues See more
Orthologs
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Genomic context

See Dmbt1 in Genome Data Viewer
Location:
7; 7 F3
Exon count:
51
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130633787..130723357)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131032057..131121628)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (138175590..138265142)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Neighboring gene microRNA 7061 Neighboring gene HtrA serine peptidase 1 Neighboring gene RIKEN cDNA 4933402N03 gene Neighboring gene RIKEN cDNA 1700029B22 gene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoteichoic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables zymogen binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of bacterial lipoprotein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in induction of bacterial agglutination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner cell mass cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deleted in malignant brain tumors 1 protein
Names
apactin
crp-ductin
deleted in malignant brain tumors 1 pseudogene
ebnerin
glycoprotein 300
hensin
mucin-like glycoprotein
muclin
vomeroglandin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347632.2NP_001334561.1  deleted in malignant brain tumors 1 protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB005909, AC087063, AC110885, LXEJ02004976
    Consensus CDS
    CCDS85436.1
    UniProtKB/Swiss-Prot
    Q60997
    Related
    ENSMUSP00000146685.3, ENSMUST00000208311.4
  2. NM_007769.3NP_031795.2  deleted in malignant brain tumors 1 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_031795.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB005909, AC087063, AC110885, LXEJ02004976
    Consensus CDS
    CCDS21909.1
    UniProtKB/Swiss-Prot
    Q60997
    Related
    ENSMUSP00000081556.5, ENSMUST00000084509.7
    Conserved Domains (5) summary
    smart00202
    Location:324424
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:16131860
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14941602
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17311858
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13761471
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    130633787..130723357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507307.5XP_006507370.2  deleted in malignant brain tumors 1 protein isoform X9

    Conserved Domains (2) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    cd00041
    Location:9991107
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  2. XM_006507302.5XP_006507365.2  deleted in malignant brain tumors 1 protein isoform X5

    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17281975
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:16091717
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  3. XM_006507298.5XP_006507361.2  deleted in malignant brain tumors 1 protein isoform X1

    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17281975
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:16091717
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  4. XM_006507299.5XP_006507362.2  deleted in malignant brain tumors 1 protein isoform X2

    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17181965
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15991707
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  5. XM_006507304.5XP_006507367.2  deleted in malignant brain tumors 1 protein isoform X6

    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:16021849
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14831591
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  6. XM_006507306.5XP_006507369.2  deleted in malignant brain tumors 1 protein isoform X8

    Related
    ENSMUSP00000148657.2, ENSMUST00000213064.3
    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:15891836
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14701578
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  7. XM_006507305.5XP_006507368.2  deleted in malignant brain tumors 1 protein isoform X7

    Conserved Domains (3) summary
    smart00202
    Location:718818
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:15901837
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14711579
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  8. XM_006507301.5XP_006507364.2  deleted in malignant brain tumors 1 protein isoform X4

    Conserved Domains (3) summary
    smart00202
    Location:428528
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17171964
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15981706
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  9. XM_006507300.5XP_006507363.2  deleted in malignant brain tumors 1 protein isoform X3

    Conserved Domains (3) summary
    smart00202
    Location:428528
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17171964
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15981706
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019334.1: Suppressed sequence

    Description
    NG_019334.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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