Crym crystallin, mu [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crymprovided by MGI
Official Full Name: crystallin, muprovided by MGI
Primary source: MGI:MGI:102675
See related: Ensembl:ENSMUSG00000030905 AllianceGenome:MGI:102675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables hormone binding activity. Acts upstream of or within thyroid hormone metabolic process. Located in mitochondrion and nucleus. Is expressed in several structures, including brain; genitourinary system; respiratory system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 23.7), cortex adult (RPKM 16.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 64.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119785603..119801212, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (120186380..120201989, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crym-positive striatal astrocytes gate perseverative behaviour.
Title: Crym-positive striatal astrocytes gate perseverative behaviour.
results suggest that CRYM deficiency leads to obesity and lipogenesis, possibly in part through increasing the food intake of mice fed a high-fat diet.
Title: Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice.
The results demonstrated that Crym is a crucial regulator of muscle plasticity, controlling metabolic and contractile properties of myofibers, and thus the selective inactivation of Crym may be a potential therapeutic target for muscle-wasting diseases.
Title: μ-Crystallin controls muscle function through thyroid hormone action.
Reduction of Crym expression in Huntington's disease (HD) could render striatal neurons more susceptible to mutant huntingtin suggesting that Crym may be a key determinant of the vulnerability of the striatum.
Title: Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration.
Title: Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells.
Comparison of the apo and NADPH forms reveals a rearrangement of the protein upon NADPH binding that reduces the degrees of freedom of several residues and traps the conformation of the binding pocket in a more T3 competent state.
Title: Crystal structure of mouse mu-crystallin complexed with NADPH and the T3 thyroid hormone.
The expression of mu-crystallin was regulated through the AP-1 site in the promoter.
Title: Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.
CRYM plays an important role in the development of the second peak of murine EIU.
Title: {mu}-Crystallin, new candidate protein in endotoxin-induced uveitis.
Disruption of the CRYM gene decreases T(3) concentrations in tissues and serum without alteration of peripheral T(3) action in vivo.
Title: micro-Crystallin as an intracellular 3,5,3'-triiodothyronine holder in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crym (e-PCR), detects polymorphism
- UniSTS:471307

AF039391 (e-PCR)
- UniSTS:179634

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables thiomorpholine-carboxylate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thyroid hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ketimine reductase mu-crystallin

Names: NADP-regulated thyroid-hormone-binding protein; mu-crystallin homolog; thiomorpholine-carboxylate dehydrogenase

NP_057878.1

EC 1.5.1.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.