Csrp2 cysteine and glycine-rich protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csrp2provided by MGI
Official Full Name: cysteine and glycine-rich protein 2provided by MGI
Primary source: MGI:MGI:1202907
See related: Ensembl:ENSMUSG00000020186 AllianceGenome:MGI:1202907
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crp2; SmLim
Summary: Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development and sarcomere organization. Predicted to act upstream of or within cell differentiation. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; cranium; genitourinary system; and gut. Orthologous to human CSRP2 (cysteine and glycine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 126.9), CNS E11.5 (RPKM 76.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 57.84 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (110756037..110775375)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (110920176..110939514)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-beta signaling promotes desmoid tumor formation via CSRP2 upregulation.
Title: TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation.
It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis.
Title: Non-Hsp genes are essential for HSF1-mediated maintenance of whole body homeostasis.
CRP2 sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
Title: Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration.
CRP2 localization dynamics, which affect CRP2 function, are regulated by the formation of actin stress fibers in conjunction with smooth muscle cell differentiation.
Title: Regulation of cysteine-rich protein 2 localization by the development of actin fibers during smooth muscle cell differentiation.
Although CRP2 expression during development is independent of CArG box, its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors.
Title: Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature.
Lack of Csrp2 is associated with alterations in cardiomyocyte thickness and hypertrophy in mice.
Title: Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.
TGFbeta activates ATF2 phosphorylation and Csrp2 gene expression via a CRE promoter element.
Title: Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.
CRP2 is a new downstream effector of cGMP/cGMP-dependent protein kinase I (cGKI)-mediated spinal nociceptive processing that plays an inhibitory role in the generation of inflammatory pain.
Title: Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.
Presence of vascular smooth muscle cell-specific element(s) within bp -573 to -550 of CSRP2 5'-flanking sequence. Transcriptional regulation of CSRP2 gene is not dependent on dominant-negative serum response factor.
Title: Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature.
CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity.
Title: LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S4161 (e-PCR)
- UniSTS:910

AW551867 (e-PCR)
- UniSTS:180118

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine and glycine-rich protein 2

Names: DLP-1; cysteine-rich protein 2; double LIM protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007792.4 → NP_031818.3 cysteine and glycine-rich protein 2

See identical proteins and their annotated locations for NP_031818.3

Status: VALIDATED

Source sequence(s)

AK012647, BY333413, CK031156

Consensus CDS

CCDS24165.1

UniProtKB/Swiss-Prot

P97314, Q9CZG5

UniProtKB/TrEMBL

Q71V27, Q9D1M8

Related

ENSMUSP00000020403.6, ENSMUST00000020403.7

Conserved Domains (2) summary

cd09480
Location:9 → 63

LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)

cd09840
Location:119 → 172

LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)