Cst8 cystatin 8 (cystatin-related epididymal spermatogenic) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cst8provided by MGI
Official Full Name: cystatin 8 (cystatin-related epididymal spermatogenic)provided by MGI
Primary source: MGI:MGI:107161
See related: Ensembl:ENSMUSG00000027442 AllianceGenome:MGI:107161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cres; Cst-rs1
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Located in cell surface; cytoplasm; and extracellular region. Is expressed in epididymis; gonad; and urogenital ridge. Orthologous to human CST8 (cystatin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 110.3) and testis adult (RPKM 50.1) See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148640759..148647516)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148798839..148805596)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Abeta assembly.
Title: Cross-seeding between the functional amyloidogenic CRES and CRES3 family members and their regulation of Aβ assembly.
Maturation of the functional mouse CRES amyloid from globular form.
Title: Maturation of the functional mouse CRES amyloid from globular form.
A 14-kDa CRES isoform resides in the outer dense fibers of the sperm tail.
Title: A population of CRES resides in the outer dense fibers of spermatozoa.
data on the antimicrobial activities of CRES protein suggest that it is a novel and innate antimicrobial protein which protecting the male reproductive tract against invading pathogens
Title: Antimicrobial activity and molecular mechanism of the CRES protein.
CRES may be a regulator of PC4 in sperm-egg interaction and fertilization.
Title: In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4.
loss of CRES has a significant impact on the structure and functions of the testis and epididymis. However, the observed pathologies were prevalent in aged but not in younger adult mice, suggesting that the effects of the loss of CRES are cumulative
Title: Alterations in the testis and epididymis associated with loss of function of the cystatin-related epididymal spermatogenic (CRES) protein.
These results suggest that mice lacking CRES may have altered local levels of cAMP/PKA activity, or that the CRES defect does not directly involve cAMP/PKA but other signaling pathways that regulate protein tyrosine phosphorylation and capacitation.
Title: Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine.
The Cres gene displays a specific age-dependent expression pattern in mouse testis and epididymis on both the mRNA and protein level.
Title: Age-dependent expression of the cystatin-related epididymal spermatogenic (Cres) gene in mouse testis and epididymis.
cystatin-related epididymal spermatogenic protein (CRES) is a competitive inhibitor of prohormone convertase 2 and may regulate proprotein processing within the reproductive and neuroendocrine systems
Title: The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2.
Cres promoter contains the DNA elements necessary for germ cell and pituitary gland-specific expression but lacks critical sequences necessary for expression in the epididymis and ovary.
Title: Recapitulation of germ cell- and pituitary-specific expression with 1.6 kb of the cystatin-related epididymal spermatogenic (Cres) gene promoter in transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Cst8 (e-PCR), detects polymorphism
- UniSTS:525892

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cystatin-8

Names: cystatin-related epididymal spermatogenic protein; cystatin-related epididymal-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.