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Ctbp1 C-terminal binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13016, updated on 8-Jul-2021

Summary

Official Symbol
Ctbp1provided by MGI
Official Full Name
C-terminal binding protein 1provided by MGI
Primary source
MGI:MGI:1201685
See related
Ensembl:ENSMUSG00000037373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B; BARS; CtBP3/; D4S115; D4S115h; D5H4S11; D5H4S115; D5H4S115E; CtBP3/BARS
Expression
Ubiquitous expression in ovary adult (RPKM 109.8), CNS E14 (RPKM 100.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ctbp1 in Genome Data Viewer
Location:
5 B1; 5 17.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33405067..33432467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33247723..33275004, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33590372..33617618, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene spondin 2, extracellular matrix protein Neighboring gene predicted gene, 54327 Neighboring gene predicted gene, 51410 Neighboring gene predicted gene 20465

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-terminal-binding protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198859.1NP_001185788.1  C-terminal-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001185788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. It encodes a shorter isoform (1) compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001198860.1NP_001185789.1  C-terminal-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001185789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes a shorter isoform (2) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    Consensus CDS
    CCDS80256.1
    UniProtKB/Swiss-Prot
    O88712
    UniProtKB/TrEMBL
    A0A0J9YU62
    Related
    ENSMUSP00000144024.2, ENSMUST00000202868.4
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001198861.1NP_001185790.1  C-terminal-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001185790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 3. It encodes a shorter isoform (4) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK133816, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. NM_001310535.1NP_001297464.1  C-terminal-binding protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 3. It encodes a shorter isoform (5) with a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC115070
    Consensus CDS
    CCDS80255.1
    UniProtKB/Swiss-Prot
    O88712
    Related
    ENSMUSP00000144554.2, ENSMUST00000201575.4
    Conserved Domains (1) summary
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. NM_013502.3NP_038530.1  C-terminal-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_038530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AK133816, BE991938, CJ163412
    Consensus CDS
    CCDS19201.1
    UniProtKB/Swiss-Prot
    O88712
    Related
    ENSMUSP00000078682.7, ENSMUST00000079746.10
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33405067..33432467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254105.2XP_030109965.1  C-terminal-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
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