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Ctse cathepsin E [ Mus musculus (house mouse) ]

Gene ID: 13034, updated on 5-Aug-2022

Summary

Official Symbol
Ctseprovided by MGI
Official Full Name
cathepsin Eprovided by MGI
Primary source
MGI:MGI:107361
See related
Ensembl:ENSMUSG00000004552 AllianceGenome:MGI:107361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CE; CatE; A430072O03Rik; C920004C08Rik
Summary
This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]
Expression
Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 70.7) and 3 other tissues See more
Orthologs
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Genomic context

See Ctse in Genome Data Viewer
Location:
1 E4; 1 57.14 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131566052..131603245)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131638314..131675507)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (133534891..133572084)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene RAB7B, member RAS oncogene family Neighboring gene predicted gene, 30104

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007799.3NP_031825.2  cathepsin E preproprotein

    See identical proteins and their annotated locations for NP_031825.2

    Status: REVIEWED

    Source sequence(s)
    AC120217, AC138277, AK145875
    Consensus CDS
    CCDS15271.1
    UniProtKB/Swiss-Prot
    P70269, Q4FK00
    Related
    ENSMUSP00000073072.7, ENSMUST00000073350.13
    Conserved Domains (3) summary
    pfam00026
    Location:78395
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:2250
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:79394
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131566052..131603245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)