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Ctss cathepsin S [ Mus musculus (house mouse) ]

Gene ID: 13040, updated on 12-Sep-2021

Summary

Official Symbol
Ctssprovided by MGI
Official Full Name
cathepsin Sprovided by MGI
Primary source
MGI:MGI:107341
See related
Ensembl:ENSMUSG00000038642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cats
Summary
This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]
Expression
Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues See more
Orthologs
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Genomic context

See Ctss in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95434097..95463716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95526786..95556405)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95330708..95360325)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cathepsin K Neighboring gene predicted gene, 40096 Neighboring gene high mobility group box 1, pseudogene 5 Neighboring gene HORMA domain containing 1 Neighboring gene predicted gene, 40097 Neighboring gene golgi phosphoprotein 3-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of peptide antigen ISO
Inferred from Sequence Orthology
more info
 
involved_in basement membrane disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in cellular protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis involved in cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cathepsin S
Names
Cat S
NP_001254624.2
NP_067256.4
XP_006501038.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267695.2NP_001254624.2  cathepsin S isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092203, AK028366, AK150274, BB072817
    Consensus CDS
    CCDS71291.1
    UniProtKB/TrEMBL
    F6WR04, Q3UD32, Q8BSZ5
    Related
    ENSMUSP00000015667.4, ENSMUST00000015667.9
    Conserved Domains (2) summary
    smart00848
    Location:3796
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:124339
    Peptidase_C1; Papain family cysteine protease
  2. NM_021281.3NP_067256.4  cathepsin S isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_067256.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK028366, BB072817
    Consensus CDS
    CCDS50992.1
    UniProtKB/Swiss-Prot
    O70370
    UniProtKB/TrEMBL
    Q8BSZ5
    Related
    ENSMUSP00000112006.3, ENSMUST00000116304.3
    Conserved Domains (2) summary
    smart00848
    Location:3695
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:123338
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95434097..95463716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500975.4XP_006501038.2  cathepsin S isoform X1

    Conserved Domains (1) summary
    pfam00112
    Location:42257
    Peptidase_C1; Papain family cysteine protease
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