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Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13074, updated on 5-Jan-2022

Summary

Official Symbol
Cyp17a1provided by MGI
Official Full Name
cytochrome P450, family 17, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88586
See related
Ensembl:ENSMUSG00000003555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp17; p450c17
Summary
Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in axon and neuronal cell body. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina layer. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in ovary adult (RPKM 93.6), testis adult (RPKM 75.6) and 3 other tissues See more
Orthologs
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Genomic context

See Cyp17a1 in Genome Data Viewer
Location:
19 C3; 19 38.97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46655604..46661439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46667165..46673000, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (46741655..46747490, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 like Neighboring gene predicted gene, 36602 Neighboring gene Cyp17a1 promoter Neighboring gene predicted gene, 41857 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene BLOC-1 related complex subunit 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 17-alpha-hydroxyprogesterone aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 17-alpha-hydroxyprogesterone aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables steroid 17-alpha-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid 17-alpha-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid 17-alpha-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables steroid 17-alpha-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within glucocorticoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hormone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
steroid 17-alpha-hydroxylase/17,20 lyase
Names
17-alpha-hydroxyprogesterone aldolase
CYPXVII
cytochrome P450 17A1
cytochrome P450, 17
cytochrome P450, 17a1
cytochrome P450-C17
cytochrome P450c17
steroid 17-alpha hydroxylase
steroid 17-alpha-monooxygenase
NP_031835.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007809.3NP_031835.3  steroid 17-alpha-hydroxylase/17,20 lyase precursor

    See identical proteins and their annotated locations for NP_031835.3

    Status: VALIDATED

    Source sequence(s)
    AK134376, CD552634, M64863
    Consensus CDS
    CCDS29882.1
    UniProtKB/Swiss-Prot
    P27786
    UniProtKB/TrEMBL
    Q3UYU1, Q53YJ1
    Related
    ENSMUSP00000026012.8, ENSMUST00000026012.8
    Conserved Domains (1) summary
    pfam00067
    Location:28492
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46655604..46661439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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