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Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 [ Mus musculus (house mouse) ]

Gene ID: 13085, updated on 23-Jun-2021

Summary

Official Symbol
Cyp2a12provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily a, polypeptide 12provided by MGI
Primary source
MGI:MGI:105055
See related
Ensembl:ENSMUSG00000060407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Restricted expression toward liver adult (RPKM 255.5) See more
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Genomic context

See Cyp2a12 in Genome Data Viewer
Location:
7; 7 A3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26728515..26736243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27029090..27036818)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27814109..27821837)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 2A8-like Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 22 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene Neighboring gene predicted gene, 51444 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene predicted gene, 29754

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables coumarin 7-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in coumarin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2A12
Names
CYPIIA12
cytochrome P450, 2a12
steroid hormones 7-alpha-hydroxylase
testosterone 7-alpha-hydroxylase
NP_598418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133657.1NP_598418.1  cytochrome P450 2A12 precursor

    See identical proteins and their annotated locations for NP_598418.1

    Status: VALIDATED

    Source sequence(s)
    BC018356
    Consensus CDS
    CCDS21009.1
    UniProtKB/Swiss-Prot
    P56593
    Related
    ENSMUSP00000074990.6, ENSMUST00000075552.7
    Conserved Domains (1) summary
    pfam00067
    Location:33489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26728515..26736243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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