U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dao D-amino acid oxidase [ Mus musculus (house mouse) ]

Gene ID: 13142, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Daoprovided by MGI
Official Full Name
D-amino acid oxidaseprovided by MGI
Primary source
MGI:MGI:94859
See related
Ensembl:ENSMUSG00000042096 AllianceGenome:MGI:94859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAAO; Dao1; DAMOX; Dao-1
Summary
Enables D-amino-acid oxidase activity and FAD binding activity. Involved in D-alanine catabolic process. Acts upstream of or within leucine metabolic process. Predicted to be located in cytosol and peroxisomal membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrial outer membrane. Is expressed in metanephros; renal cortex; ureter; and urinary system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 130.9), duodenum adult (RPKM 16.0) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 F; 5 55.93 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114137696..114163736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113999635..114025675)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22056 Neighboring gene slingshot protein phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_14062 Neighboring gene predicted gene, 52826 Neighboring gene SV2 related protein Neighboring gene predicted gene 16108 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression. Oshima Y, et al. Sci Rep, 2023 Feb 27. PMID 36849798, Free PMC Article
  2. Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum. Cuomo M, et al. Clin Epigenetics, 2019 Oct 28. PMID 31661019, Free PMC Article
  3. Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration. Kim SH, et al. J Biochem, 2019 Aug 1. PMID 30938755
  4. Variations of L- and D-amino acid levels in the brain of wild-type and mutant mice lacking D-amino acid oxidase activity. Du S, et al. Anal Bioanal Chem, 2018 May. PMID 29532193
  5. Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. Kondori NR, et al. PLoS One, 2017. PMID 29194436, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.
    Title: Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.
  2. Study demonstrates that robust and selective demethylation of two CpG sites is associated with postnatal activation of the Dao gene and consequent removal of D-serine within the cerebellum.
    Title: Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.
  3. We show that prolonged treatment with selegiline fails to reduce aberrant astrocytic GABA levels and rescue memory impairment in APP/PS1 mice, an animal model of AD, because of increased activity in compensatory genes for a GABA-synthesizing enzyme, diamine oxidase (DAO)
    Title: Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.
  4. age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration
    Title: Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration.
  5. This work provides the most complete baseline analysis of L- and D-amino acids in the brains of wild-type and mutant mice lacking D-amino acid oxidase activity.
    Title: Variations of L- and D-amino acid levels in the brain of wild-type and mutant mice lacking D-amino acid oxidase activity.
  6. findings reveal that DAO is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine
    Title: Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota.
  7. some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS
    Title: Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.
  8. Long-term spatial memory is unaltered in Dao-/- mice.
    Title: Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao(-/-)) mice.
  9. Dao-/- mice demonstrated enhanced spatial recognition memory and no sleep or circadian rhythm disruption.
    Title: d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.
  10. In d-Amino acid oxidase (-/-) mice, approximately twice as many Dopamine-like neurons fired in a bursting pattern than in DAO(+/-) or DAO(+/+) mice. Data provide the first direct evidence that DAO modulates VTA DA neuron activity
    Title: Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-amino-acid dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables D-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-amino-acid oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-amino-acid oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-alanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-alanine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-alanine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in D-amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in D-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-serine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in D-serine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within L-leucine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in digestion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in killing by host of symbiont cells IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil-mediated killing of gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proline catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
D-amino-acid oxidase
Names
D-amino acid oxidase 1
NP_001273325.1
NP_001273326.1
NP_034148.2
XP_006530224.1
XP_006530225.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286396.1 → NP_001273325.1  D-amino-acid oxidase isoform 1

    See identical proteins and their annotated locations for NP_001273325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC145559
    Consensus CDS
    CCDS19557.1
    UniProtKB/Swiss-Prot
    P18894, Q64465, Q8VCW7
    UniProtKB/TrEMBL
    A0A0R4J203
    Related
    ENSMUSP00000125588.2, ENSMUST00000161610.6
    Conserved Domains (2) summary
    pfam01266
    Location:35 → 327
    DAO; FAD dependent oxidoreductase
    cl21454
    Location:1 → 24
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001286397.1 → NP_001273326.1  D-amino-acid oxidase isoform 2

    See identical proteins and their annotated locations for NP_001273326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC145559
    Consensus CDS
    CCDS71641.1
    UniProtKB/TrEMBL
    Q91WH3
    Related
    ENSMUSP00000083792.5, ENSMUST00000086599.11
    Conserved Domains (1) summary
    pfam01266
    Location:2 → 226
    DAO; FAD dependent oxidoreductase

  3. NM_010018.3 → NP_034148.2  D-amino-acid oxidase isoform 1

    See identical proteins and their annotated locations for NP_034148.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC145559, AK134813, AW492600, BU755879
    Consensus CDS
    CCDS19557.1
    UniProtKB/Swiss-Prot
    P18894, Q64465, Q8VCW7
    UniProtKB/TrEMBL
    A0A0R4J203
    Related
    ENSMUSP00000107911.3, ENSMUST00000112292.9
    Conserved Domains (2) summary
    pfam01266
    Location:35 → 327
    DAO; FAD dependent oxidoreductase
    cl21454
    Location:1 → 24
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114137696..114163736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530162.4 → XP_006530225.1  D-amino-acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_006530225.1

    UniProtKB/Swiss-Prot
    P18894, Q64465, Q8VCW7
    UniProtKB/TrEMBL
    A0A0R4J203
    Conserved Domains (2) summary
    pfam01266
    Location:35 → 327
    DAO; FAD dependent oxidoreductase
    cl21454
    Location:1 → 24
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006530161.2 → XP_006530224.1  D-amino-acid oxidase isoform X1

    See identical proteins and their annotated locations for XP_006530224.1

    UniProtKB/Swiss-Prot
    P18894, Q64465, Q8VCW7
    UniProtKB/TrEMBL
    A0A0R4J203
    Conserved Domains (2) summary
    pfam01266
    Location:35 → 327
    DAO; FAD dependent oxidoreductase
    cl21454
    Location:1 → 24
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18894.3 GenPept UniProtKB/Swiss-Prot:P18894

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous