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Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [ Mus musculus (house mouse) ]

Gene ID: 13162, updated on 21-Jun-2022

Summary

Official Symbol
Slc6a3provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3provided by MGI
Primary source
MGI:MGI:94862
See related
Ensembl:ENSMUSG00000021609 AllianceGenome:MGI:94862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAT; Dat1
Summary
Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Slc6a3 in Genome Data Viewer
Location:
13 C1; 13 40.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73684270..73726791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73536128..73578672)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (73674195..73716120)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ephemeron, early developmental lncRNA Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene Tert 5' regulatory region Neighboring gene CLPTM1-like Neighboring gene telomerase reverse transcriptase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amine binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dopamine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dopamine:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dopamine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables neurotransmitter transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables norepinephrine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake involved in synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaloid vascular plexus regression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoamine transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in neurotransmitter transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of flotillin complex ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium-dependent dopamine transporter
Names
DA transporter
dopamine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010020.3NP_034150.1  sodium-dependent dopamine transporter

    See identical proteins and their annotated locations for NP_034150.1

    Status: VALIDATED

    Source sequence(s)
    AC154547, AC158359
    Consensus CDS
    CCDS26632.1
    UniProtKB/Swiss-Prot
    Q61327
    Related
    ENSMUSP00000022100.7, ENSMUST00000022100.7
    Conserved Domains (1) summary
    cl00456
    Location:60613
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73684270..73726791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517083.5XP_006517146.1  sodium-dependent dopamine transporter isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:60569
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_017315377.3XP_017170866.1  sodium-dependent dopamine transporter isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:60533
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_006517084.5XP_006517147.1  sodium-dependent dopamine transporter isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:60385
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain