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Dclk1 doublecortin-like kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 13175, updated on 14-Sep-2021

Summary

Official Symbol
Dclk1provided by MGI
Official Full Name
doublecortin-like kinase 1provided by MGI
Primary source
MGI:MGI:1330861
See related
Ensembl:ENSMUSG00000027797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dc; Dcl; CPG1; Clic; Dclk; Cpg16; Dcamk; Click-I; Dcamkl1; AI836758; mKIAA0369; 1700113D08Rik; 2810480F11Rik
Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
Expression
Biased expression in frontal lobe adult (RPKM 35.3), cortex adult (RPKM 34.0) and 7 other tissues See more
Orthologs
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Genomic context

See Dclk1 in Genome Data Viewer
Location:
3; 3 C
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (55149724..55446489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55242303..55539068)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (55046448..55342990)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 169 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2 Neighboring gene predicted gene, 25132 Neighboring gene predicted gene 9831 Neighboring gene predicted gene, 31443 Neighboring gene U6 spliceosomal RNA Neighboring gene predicted gene, 31796 Neighboring gene predicted gene, 25404

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase DCLK1
Names
CLICK-I beta
doublecortin and calcium/calmodulin-dependent protein kinase-like 1
doublecortin-like and CAM kinase-like 1
NP_001104521.1
NP_001104522.1
NP_001104523.1
NP_001182467.1
NP_001182468.1
NP_001182469.1
NP_001344395.1
NP_001344397.1
NP_001344398.1
NP_001344404.1
NP_001344405.1
NP_064362.1
XP_006501044.1
XP_006501045.1
XP_006501046.1
XP_017174936.1
XP_030108271.1
XP_030108272.1
XP_036018774.1
XP_036018775.1
XP_036018776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111051.2NP_001104521.1  serine/threonine-protein kinase DCLK1 isoform 2

    See identical proteins and their annotated locations for NP_001104521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as DCLK-short-A, DCK-beta2, KIAA0369-BL or cpg16 (candidate plasticity gene 16)] is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, as compared to variant 5. The resulting isoform (2) has a shorter and different N-terminus, and lacks doublecortin domains, as compared to isoform 5.
    Source sequence(s)
    AC115945, AF155821, BF467198, BY123015
    UniProtKB/TrEMBL
    Q9JLM6
    Related
    ENSMUSP00000142637.2, ENSMUST00000198412.5
    Conserved Domains (2) summary
    smart00220
    Location:83340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14183
    Location:76343
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  2. NM_001111052.2NP_001104522.1  serine/threonine-protein kinase DCLK1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as DCLK-short-B, DCK-beta1 or KIAA0369-BS ) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional exon in the 3' CDS that results in a frameshift, as compared to variant 5. The resulting isoform (3) has shorter and different N- and C-termini, and lacks doublecortin domains, as compared to isoform 5.
    Source sequence(s)
    AC115945, BF467198
    Consensus CDS
    CCDS50910.1
    UniProtKB/TrEMBL
    H7BX36
    Related
    ENSMUSP00000070292.5, ENSMUST00000070418.9
    Conserved Domains (2) summary
    smart00220
    Location:83340
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14183
    Location:76343
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  3. NM_001111053.2NP_001104523.1  serine/threonine-protein kinase DCLK1 isoform 4

    See identical proteins and their annotated locations for NP_001104523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as DCL (PMID: 17313568)) is produced from the 5' promoter. It lacks several 3' exons but has an alternate 3' exon, as compared to variant 5. The resulting isoform (4) has a shorter and distinct C-terminus, and lacks a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.
    Source sequence(s)
    AC111132, AC115945, AK147831, BC050903, CJ241697
    Consensus CDS
    CCDS50909.1
    UniProtKB/TrEMBL
    Q80VB6
    Related
    ENSMUSP00000129334.2, ENSMUST00000167204.8
    Conserved Domains (2) summary
    cd17069
    Location:182265
    DCX2; Dublecortin-like domain 2
    cd17140
    Location:55143
    DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
  4. NM_001195538.2NP_001182467.1  serine/threonine-protein kinase DCLK1 isoform 5

    See identical proteins and their annotated locations for NP_001182467.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as DCLK-long-A, DCK-alpha2, KIAA0369-AL, DCAMKL1 or zyg8) is produced from the 5' promoter. It encodes isoform 5, which includes two doublecortin domains, a serine/proline-rich domain and a protein kinase domain.
    Source sequence(s)
    AC104099, AC111132, AC115945, BF467198
    UniProtKB/TrEMBL
    A3KN70
    Conserved Domains (3) summary
    smart00220
    Location:390647
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:52142
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14183
    Location:383650
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  5. NM_001195539.2NP_001182468.1  serine/threonine-protein kinase DCLK1 isoform 6

    See identical proteins and their annotated locations for NP_001182468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as DCLK-short-C or DCK-beta2-R) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (6) has a shorter and different N-terminus, and lacks doublecortin domains but has an additional Arg-rich segment, as compared to isoform 5.
    Source sequence(s)
    AC115945, AF155821, AK032424, BF467198, BY123015
    Consensus CDS
    CCDS79909.1
    UniProtKB/TrEMBL
    Q8CCN4
    Related
    ENSMUSP00000143016.2, ENSMUST00000198437.5
    Conserved Domains (2) summary
    smart00220
    Location:99356
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14183
    Location:92359
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  6. NM_001195540.2NP_001182469.1  serine/threonine-protein kinase DCLK1 isoform 7

    See identical proteins and their annotated locations for NP_001182469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is produced from the 3' promoter. It shares only one exon with variant 5, and encodes a 56 aa isoform [7, also known as ania-4, or CARP (CaMK-related peptide)], which mainly consists of the serine/proline-rich domain.
    Source sequence(s)
    AC115945, BY126617
    Consensus CDS
    CCDS79908.1
    UniProtKB/TrEMBL
    A8IP62
    Related
    ENSMUSP00000142698.2, ENSMUST00000199585.5
  7. NM_001357466.1NP_001344395.1  serine/threonine-protein kinase DCLK1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC104099, AC111132, AC115945, BF467198
    Conserved Domains (2) summary
    smart00537
    Location:52142
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14183
    Location:383650
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  8. NM_001357468.1NP_001344397.1  serine/threonine-protein kinase DCLK1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC115945, BF467198
    Conserved Domains (1) summary
    cd14183
    Location:92359
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  9. NM_001357469.1NP_001344398.1  serine/threonine-protein kinase DCLK1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC104099, AC111132, AC115945, BF467198
    Conserved Domains (2) summary
    smart00537
    Location:52142
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14183
    Location:399666
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  10. NM_001357475.1NP_001344404.1  serine/threonine-protein kinase DCLK1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC104099, AC111132, AC115945, BF467198
    Consensus CDS
    CCDS89626.1
    Related
    ENSMUSP00000143659.2, ENSMUST00000196745.5
    Conserved Domains (2) summary
    smart00537
    Location:52142
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14183
    Location:383649
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  11. NM_001357476.1NP_001344405.1  serine/threonine-protein kinase DCLK1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC115945, BF467198
    Consensus CDS
    CCDS89627.1
    Related
    ENSMUSP00000143507.2, ENSMUST00000199702.5
    Conserved Domains (1) summary
    cd14183
    Location:75342
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  12. NM_019978.4NP_064362.1  serine/threonine-protein kinase DCLK1 isoform 1

    See identical proteins and their annotated locations for NP_064362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as DCLK-long-C, DCK-alpha2-R) is produced from the 5' promoter. It has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (1) is the longest isoform which includes an Arg-rich domain, in addition to two doublecortin domains, a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.
    Source sequence(s)
    AC111132, AC115945, AF155819, BF467198
    Consensus CDS
    CCDS17359.1
    UniProtKB/Swiss-Prot
    Q9JLM8
    Related
    ENSMUSP00000050034.8, ENSMUST00000054237.14
    Conserved Domains (3) summary
    smart00220
    Location:406663
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00537
    Location:52142
    DCX; Domain in the Doublecortin (DCX) gene product
    cd14183
    Location:399666
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    55149724..55446489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319447.3XP_017174936.1  serine/threonine-protein kinase DCLK1 isoform X1

    Conserved Domains (3) summary
    cd14183
    Location:399666
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    cd17069
    Location:182265
    DCX2; Dublecortin-like domain 2
    cd17140
    Location:55143
    DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
  2. XM_036162883.1XP_036018776.1  serine/threonine-protein kinase DCLK1 isoform X8

    Conserved Domains (2) summary
    cd17069
    Location:182265
    DCX2; Dublecortin-like domain 2
    cd17140
    Location:55143
    DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
  3. XM_006500983.5XP_006501046.1  serine/threonine-protein kinase DCLK1 isoform X8

    See identical proteins and their annotated locations for XP_006501046.1

    UniProtKB/TrEMBL
    Q80VB6
    Conserved Domains (2) summary
    cd17069
    Location:182265
    DCX2; Dublecortin-like domain 2
    cd17140
    Location:55143
    DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
  4. XM_006500982.3XP_006501045.1  serine/threonine-protein kinase DCLK1 isoform X7

    See identical proteins and their annotated locations for XP_006501045.1

    UniProtKB/TrEMBL
    Q8BRN4
    Conserved Domains (2) summary
    cd17069
    Location:182265
    DCX2; Dublecortin-like domain 2
    cd17140
    Location:55143
    DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
  5. XM_030252412.2XP_030108272.1  serine/threonine-protein kinase DCLK1 isoform X6

    Conserved Domains (1) summary
    cd14183
    Location:42309
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  6. XM_006500981.5XP_006501044.1  serine/threonine-protein kinase DCLK1 isoform X2

    See identical proteins and their annotated locations for XP_006501044.1

    Conserved Domains (1) summary
    cd14183
    Location:58325
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  7. XM_030252411.2XP_030108271.1  serine/threonine-protein kinase DCLK1 isoform X4

    Conserved Domains (1) summary
    cd14183
    Location:42309
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  8. XM_036162882.1XP_036018775.1  serine/threonine-protein kinase DCLK1 isoform X5

    Conserved Domains (1) summary
    cd14183
    Location:41308
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
  9. XM_036162881.1XP_036018774.1  serine/threonine-protein kinase DCLK1 isoform X3

    Conserved Domains (1) summary
    cd14183
    Location:57324
    STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

RNA

  1. XR_004941275.1 RNA Sequence

  2. XR_004941274.1 RNA Sequence

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