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Dck deoxycytidine kinase [ Mus musculus (house mouse) ]

Gene ID: 13178, updated on 5-Sep-2021

Summary

Official Symbol
Dckprovided by MGI
Official Full Name
deoxycytidine kinaseprovided by MGI
Primary source
MGI:MGI:102726
See related
Ensembl:ENSMUSG00000029366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in liver E14 (RPKM 26.6), liver E14.5 (RPKM 23.2) and 17 other tissues See more
Orthologs
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Genomic context

See Dck in Genome Data Viewer
Location:
5; 5 E1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88912872..88931136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88765013..88783277)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (89194038..89212302)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene MOB kinase activator 1B Neighboring gene predicted gene 15682 Neighboring gene solute carrier family 4 (anion exchanger), member 4 Neighboring gene makorin, ring finger protein 1, pseudogene 1 Neighboring gene predicted gene, 35855

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables deoxyadenosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables deoxycytidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxycytidine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables deoxyguanosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables deoxynucleoside kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyribonucleoside binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyrimidine deoxyribonucleoside binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dAMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dGMP salvage TAS
Traceable Author Statement
more info
PubMed 
involved_in deoxycytidine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in pyrimidine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol TAS
Traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
deoxycytidine kinase
Names
deoxyadenosine kinase
deoxyguanosine kinase
NP_031858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007832.4NP_031858.1  deoxycytidine kinase

    See identical proteins and their annotated locations for NP_031858.1

    Status: VALIDATED

    Source sequence(s)
    BC060062, BU052737
    Consensus CDS
    CCDS19405.1
    UniProtKB/Swiss-Prot
    P43346
    UniProtKB/TrEMBL
    Q545E8
    Related
    ENSMUSP00000031311.10, ENSMUST00000031311.10
    Conserved Domains (2) summary
    COG0125
    Location:24257
    Tmk; Thymidylate kinase [Nucleotide transport and metabolism]
    pfam01712
    Location:24258
    dNK; Deoxynucleoside kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88912872..88931136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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