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Dcx doublecortin [ Mus musculus (house mouse) ]

Gene ID: 13193, updated on 31-Aug-2021

Summary

Official Symbol
Dcxprovided by MGI
Official Full Name
doublecortinprovided by MGI
Primary source
MGI:MGI:1277171
See related
Ensembl:ENSMUSG00000031285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dbct
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Biased expression in whole brain E14.5 (RPKM 80.1), CNS E18 (RPKM 75.8) and 3 other tissues See more
Orthologs
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Genomic context

See Dcx in Genome Data Viewer
Location:
X; X F2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (142638838..142716392, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (143855842..143933396, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (140290385..140367762, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 3 Neighboring gene calpain 6 Neighboring gene predicted gene, 33039 Neighboring gene predicted gene 15048

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in photoreceptor cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pyramidal neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in retina development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuronal migration protein doublecortin
Names
doublecortex
doublin
lis-X
lissencephalin-X
lissencephaly, X-linked (doublecortin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110222.1NP_001103692.1  neuronal migration protein doublecortin isoform a

    See identical proteins and their annotated locations for NP_001103692.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB011678, AK164139, BC056391, CJ102759
    Consensus CDS
    CCDS53209.1
    UniProtKB/Swiss-Prot
    O88809
    UniProtKB/TrEMBL
    Q6PGI2
    Related
    ENSMUSP00000084570.4, ENSMUST00000087313.10
    Conserved Domains (2) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
  2. NM_001110223.1NP_001103693.1  neuronal migration protein doublecortin isoform a

    See identical proteins and their annotated locations for NP_001103693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB011678, AK164139, BC056391
    Consensus CDS
    CCDS53209.1
    UniProtKB/Swiss-Prot
    O88809
    UniProtKB/TrEMBL
    Q6PGI2
    Related
    ENSMUSP00000033642.4, ENSMUST00000033642.10
    Conserved Domains (2) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
  3. NM_001110224.1NP_001103694.1  neuronal migration protein doublecortin isoform b

    See identical proteins and their annotated locations for NP_001103694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in one aa less (isoform b), compared to isoform a.
    Source sequence(s)
    AB011678, AK164139, BC056391
    Consensus CDS
    CCDS53210.1
    UniProtKB/Swiss-Prot
    O88809
    UniProtKB/TrEMBL
    Q6PGI2
    Related
    ENSMUSP00000108472.2, ENSMUST00000112851.8
    Conserved Domains (3) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
    cl40450
    Location:284343
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
  4. NM_010025.2NP_034155.2  neuronal migration protein doublecortin isoform c

    See identical proteins and their annotated locations for NP_034155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and has two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AB011678, AK014264, BC057010, CA315795, CB525395, CD350374, CD802698
    Consensus CDS
    CCDS41157.1
    UniProtKB/Swiss-Prot
    O88809
    UniProtKB/TrEMBL
    Q6PGI2, Q9CXL6
    Related
    ENSMUSP00000108477.3, ENSMUST00000112856.3
    Conserved Domains (3) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
    cl40450
    Location:284338
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    142638838..142716392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528698.4XP_006528761.1  neuronal migration protein doublecortin isoform X2

    Conserved Domains (2) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
  2. XM_030251214.2XP_030107074.1  neuronal migration protein doublecortin isoform X3

    Conserved Domains (3) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
    cl40450
    Location:284338
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
  3. XM_030251213.2XP_030107073.1  neuronal migration protein doublecortin isoform X2

    Conserved Domains (2) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
  4. XM_030251212.2XP_030107072.1  neuronal migration protein doublecortin isoform X1

    Conserved Domains (3) summary
    cd16112
    Location:51139
    DCX1_DCX; Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
    cd17069
    Location:176259
    DCX2; Dublecortin-like domain 2
    cl40450
    Location:284343
    KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
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