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Defb1 defensin beta 1 [ Mus musculus (house mouse) ]

Gene ID: 13214, updated on 23-Jun-2021

Summary

Official Symbol
Defb1provided by MGI
Official Full Name
defensin beta 1provided by MGI
Primary source
MGI:MGI:1096878
See related
Ensembl:ENSMUSG00000044748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BD-1; AW260221
Expression
Biased expression in kidney adult (RPKM 68.1), liver E18 (RPKM 11.9) and 2 other tissues See more
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Genomic context

See Defb1 in Genome Data Viewer
Location:
8 A2; 8 10.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22266571..22285201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21776555..21795185)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (22887027..22905657)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, 24 Neighboring gene defensin, alpha, pseudogene 11 Neighboring gene predicted gene 15316 Neighboring gene defensin beta 50

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR6 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR6 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of flagellated sperm motility involved in capacitation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvesicle ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007843.3NP_031869.1  beta-defensin 1 precursor

    See identical proteins and their annotated locations for NP_031869.1

    Status: VALIDATED

    Source sequence(s)
    AI956736, AK142544, DV551556
    Consensus CDS
    CCDS40282.1
    UniProtKB/Swiss-Prot
    P56386
    UniProtKB/TrEMBL
    Q3UQE2
    Related
    ENSMUSP00000051754.9, ENSMUST00000051017.9
    Conserved Domains (1) summary
    pfam00711
    Location:3568
    Defensin_beta; Beta defensin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22266571..22285201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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