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Dlx2 distal-less homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 13392, updated on 6-Jul-2021

Summary

Official Symbol
Dlx2provided by MGI
Official Full Name
distal-less homeobox 2provided by MGI
Primary source
MGI:MGI:94902
See related
Ensembl:ENSMUSG00000023391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlx-; Tes-; Dlx-2; Tes-1; AW121999
Expression
Biased expression in whole brain E14.5 (RPKM 11.5), CNS E14 (RPKM 10.5) and 5 other tissues See more
Orthologs
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Genomic context

See Dlx2 in Genome Data Viewer
Location:
2 C2; 2 42.65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71373752..71377098, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71543408..71546754, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (71381465..71384811, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene predicted gene, 54160 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 1 Neighboring gene predicted gene, 36857 Neighboring gene predicted gene, 36909

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within subpallium development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein DLX-2
Names
DII A
homeobox protein TES-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010054.2NP_034184.1  homeobox protein DLX-2

    See identical proteins and their annotated locations for NP_034184.1

    Status: VALIDATED

    Source sequence(s)
    AK144652, BC094317
    Consensus CDS
    CCDS16117.1
    UniProtKB/Swiss-Prot
    P40764
    UniProtKB/TrEMBL
    Q52KJ2
    Related
    ENSMUSP00000024159.7, ENSMUST00000024159.8
    Conserved Domains (2) summary
    pfam00046
    Location:158211
    Homeobox; Homeobox domain
    pfam12413
    Location:54135
    DLL_N; Homeobox protein distal-less-like N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71373752..71377098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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