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Dnm1 dynamin 1 [ Mus musculus (house mouse) ]

Gene ID: 13429, updated on 27-Jul-2021

Summary

Official Symbol
Dnm1provided by MGI
Official Full Name
dynamin 1provided by MGI
Primary source
MGI:MGI:107384
See related
Ensembl:ENSMUSG00000026825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnm; Ftf; Ftfl; AI838169; mKIAA4093
Summary
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Biased expression in cerebellum adult (RPKM 188.3), cortex adult (RPKM 160.9) and 14 other tissues See more
Orthologs
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Genomic context

See Dnm1 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32198483..32243361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32308471..32353349, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32163991..32208824, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SWI5 recombination repair homolog (yeast) Neighboring gene golgi autoantigen, golgin subfamily a, 2 Neighboring gene microRNA 3154 Neighboring gene microRNA 199b Neighboring gene predicted gene, 52590 Neighboring gene predicted gene, 39787

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4093

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of membrane coat IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynamin-1
NP_001288666.1
NP_001355608.1
NP_034195.2
XP_006497712.2
XP_006497713.2
XP_006497716.2
XP_006497717.2
XP_006497718.2
XP_006497721.2
XP_006497722.2
XP_006497723.2
XP_006497724.2
XP_006497725.1
XP_017170817.1
XP_036013974.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301737.1NP_001288666.1  dynamin-1 isoform 2

    See identical proteins and their annotated locations for NP_001288666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant contains the alternate "a" exon in the central coding region and the "b" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AK011651, AL808027, BC034679, BQ179370, BY297150, CA328097, CO425806
    Consensus CDS
    CCDS79772.1
    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000077461.6, ENSMUST00000078352.12
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  2. NM_001368679.1NP_001355608.1  dynamin-1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the mid-coding region and uses an alternate acceptor splice site at the 3' terminal exon compared to variant one. The resulting isoform (3) is longer than isoform 1.
    Source sequence(s)
    AL808027
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752863
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
  3. NM_010065.3NP_034195.2  dynamin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This variant contains the alternate "b" exon in the central coding region and the "a" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AA387428, AI894003, AK011651, BC058623, BE860433, BM950315, BY297150, CX239206
    Consensus CDS
    CCDS38102.1
    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000088618.6, ENSMUST00000091089.12
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:653741
    GED; Dynamin GTPase effector domain
    cl26464
    Location:743860
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_125959.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains two alternate exons in the central region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant contains the alternate "b" exon in the central region (PMID:20700442).
    Source sequence(s)
    BC034679, BY297150
    Related
    ENSMUST00000139624.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32198483..32243361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497654.4XP_006497717.2  dynamin-1 isoform X4

    See identical proteins and their annotated locations for XP_006497717.2

    UniProtKB/TrEMBL
    A0A0J9YUN4
    Related
    ENSMUSP00000144264.2, ENSMUST00000201433.4
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  2. XM_006497649.3XP_006497712.2  dynamin-1 isoform X1

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
  3. XM_006497659.4XP_006497722.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497722.2

    UniProtKB/Swiss-Prot
    P39053
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  4. XM_006497655.4XP_006497718.2  dynamin-1 isoform X5

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000108992.2, ENSMUST00000113365.8
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  5. XM_036158081.1XP_036013974.1  dynamin-1 isoform X3

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752863
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  6. XM_006497661.3XP_006497724.2  dynamin-1 isoform X8

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000108977.2, ENSMUST00000113350.8
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  7. XM_006497653.4XP_006497716.2  dynamin-1 isoform X6

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:743860
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
  8. XM_006497658.4XP_006497721.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497721.2

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000143955.2, ENSMUST00000202578.4
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  9. XM_006497650.4XP_006497713.2  dynamin-1 isoform X2

    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
  10. XM_017315328.2XP_017170817.1  dynamin-1 isoform X8

    UniProtKB/Swiss-Prot
    P39053
    Related
    ENSMUSP00000108979.3, ENSMUST00000113352.9
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
  11. XM_006497662.3XP_006497725.1  dynamin-1 isoform X9

    Conserved Domains (5) summary
    cd08771
    Location:100340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    PHA03247
    Location:793910
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:566675
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:262548
    Dynamin_M; Dynamin central region
    pfam02212
    Location:702791
    GED; Dynamin GTPase effector domain
  12. XM_006497660.3XP_006497723.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497723.2

    UniProtKB/Swiss-Prot
    P39053
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain

RNA

  1. XR_374055.3 RNA Sequence

  2. XR_004938046.1 RNA Sequence

  3. XR_001780675.2 RNA Sequence

  4. XR_004938043.1 RNA Sequence

  5. XR_004938042.1 RNA Sequence

  6. XR_004938044.1 RNA Sequence

  7. XR_374058.5 RNA Sequence

  8. XR_374057.4 RNA Sequence

  9. XR_001780678.3 RNA Sequence

  10. XR_003950433.2 RNA Sequence

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