U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dpep1 dipeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 13479, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Dpep1provided by MGI
Official Full Name
dipeptidase 1provided by MGI
Primary source
MGI:MGI:94917
See related
Ensembl:ENSMUSG00000019278 AllianceGenome:MGI:94917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBD; DPEP-1
Summary
Enables beta-lactamase activity and dipeptidase activity. Involved in several processes, including glutathione catabolic process; leukotriene metabolic process; and neutrophil chemotaxis. Predicted to be located in apical part of cell; cell junction; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system; incisor; and lung. Orthologous to human DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 182.7), small intestine adult (RPKM 109.8) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dpep1 in Genome Data Viewer
Location:
8 E1; 8 72.08 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123913069..123928551)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123186235..123201812)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57791 Neighboring gene predicted gene 4316 Neighboring gene charged multivesicular body protein 1A Neighboring gene ribosomal protein S12, pseudogene 9 Neighboring gene spermatogenesis associated 33

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Lau A, et al. Sci Adv, 2022 Feb 4. PMID 35108057, Free PMC Article
  2. Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Choudhury SR, et al. Cell, 2019 Aug 22. PMID 31442408
  3. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Habib GM, et al. Adv Exp Med Biol, 1999. PMID 10667344
  4. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Habib GM, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560193, Free PMC Article
  5. Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase. Habib GM, et al. J Biol Chem, 1996 Jul 5. PMID 8663190

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
    Title: Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
  2. A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
    Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
  3. Genetic ablation or functional peptide blocking of DPEP1 significantly reduced neutrophil recruitment to the lungs and liver and provided improved survival in models of endotoxemia.
    Title: Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.
  4. Contrast-induced acute kidney injury is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.
    Title: Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-lactamase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-lactamase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables modified amino acid binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antibiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukotriene D4 catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leukotriene metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dipeptidase 1
Names
MBD-1
beta-lactamase
dipeptidase 1 (renal)
membrane bound dipeptidase type II
membrane-bound dipeptidase 1
microsomal dipeptidase
renal dipeptidase
NP_001403941.1
NP_031902.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417012.1 → NP_001403941.1  dipeptidase 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC163617
    UniProtKB/Swiss-Prot
    G5E824, P31428

  2. NM_007876.3 → NP_031902.2  dipeptidase 1 precursor

    See identical proteins and their annotated locations for NP_031902.2

    Status: VALIDATED

    Source sequence(s)
    AC163617
    Consensus CDS
    CCDS22750.1
    UniProtKB/Swiss-Prot
    G5E824, P31428
    UniProtKB/TrEMBL
    Q99LA8
    Related
    ENSMUSP00000019422.5, ENSMUST00000019422.6
    Conserved Domains (1) summary
    pfam01244
    Location:25 → 352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123913069..123928551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31428.2 GenPept UniProtKB/Swiss-Prot:P31428

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous