Slc26a3 solute carrier family 26, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a3provided by MGI
Official Full Name: solute carrier family 26, member 3provided by MGI
Primary source: MGI:MGI:107181
See related: Ensembl:ENSMUSG00000001225 AllianceGenome:MGI:107181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dra; 9030623B18Rik; 9130013M11Rik
Summary: This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]
Expression: Biased expression in colon adult (RPKM 52.2), large intestine adult (RPKM 13.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.45 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (31483141..31523921)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (31433142..31473922)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.
Title: Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.
Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk.
Title: Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk.
Vitamin D receptor involves in the protection of intestinal epithelial barrier function via up-regulating SLC26A3.
Title: Vitamin D receptor involves in the protection of intestinal epithelial barrier function via up-regulating SLC26A3.
Slc26a3 deletion alters pH-microclimate, mucin biosynthesis, microbiome composition and increases the TNFalpha expression in murine colon.
Title: Slc26a3 deletion alters pH-microclimate, mucin biosynthesis, microbiome composition and increases the TNFα expression in murine colon.
A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.
Title: A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.
All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.
Title: All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.
Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Title: Induction of enteric oxalate secretion by Oxalobacter formigenes in mice does not require the presence of either apical oxalate transport proteins Slc26A3 or Slc26A6.
Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection has been reported in humans and mice.
Title: Decreased SLC26A3 expression and function in intestinal epithelial cells in response to Cryptosporidium parvum infection.
SLC26A3 is essential for sperm motility and protein tyrosine phosphorylation during mouse sperm capacitation process.
Title: Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse.
role in protecting the intestinal epithelial barrier
Title: SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

AV376035 (e-PCR)
- UniSTS:180376

BQ203092 (e-PCR)
- UniSTS:260769

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular pH elevation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chloride anion exchanger

Names: down-regulated in adenoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021353.3 → NP_067328.1 chloride anion exchanger

See identical proteins and their annotated locations for NP_067328.1

Status: REVIEWED

Source sequence(s)

AK018566, BC139271, CR974423

Consensus CDS

CCDS25863.1

UniProtKB/Swiss-Prot

B2RTD9, Q9WVC8

Related

ENSMUSP00000001254.6, ENSMUST00000001254.6

Conserved Domains (2) summary

cd07042
Location:519 → 705

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:73 → 468

Sulfate_transp; Sulfate permease family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

31483141..31523921

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314950.1 → XP_017170439.1 chloride anion exchanger isoform X1

UniProtKB/Swiss-Prot

B2RTD9, Q9WVC8

Conserved Domains (2) summary

cd07042
Location:519 → 705

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:73 → 468

Sulfate_transp; Sulfate permease family
XM_011243812.1 → XP_011242114.1 chloride anion exchanger isoform X2

Conserved Domains (1) summary

TIGR00815
Location:3 → 396

sulP; high affinity sulphate transporter 1